Evidence map›Paper›PMID 24282204›Full record

SynthesisBritish journal of sports medicine2013

Altitude training and haemoglobin mass from the optimised carbon monoxide rebreathing method determined by a meta-analysis.

Christopher J Gore, Ken Sharpe, Laura A Garvican-Lewis, Philo U Saunders, Clare E Humberstone, Eileen Y Robertson, Nadine B Wachsmuth, Sally A Clark, Blake D McLean, Birgit Friedmann-Bette and 4 more

Registry-linked trialAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of sports medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07337928 (Altitude Training Effectiveness; Is There a Role for Sleep and Menstrual Health?), which is not on this map. Cited by 80 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07337928 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Altitude Training Effectiveness; Is There a Role for Sleep and Menstrual Health?

Typeobservational_patient_registrySponsorVrije Universiteit BrusselRan2026 to 2026Enrolled30ConditionsAltitude Effectiveness
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Christopher J GoreDepartment of Physiology, Australian Institute of Sport, , Canberra, Australia.
Ken Sharpe
Laura A Garvican-Lewis
Philo U Saunders
Clare E Humberstone
Eileen Y Robertson
Nadine B Wachsmuth
Sally A Clark
Blake D McLean
Birgit Friedmann-Bette
Mitsuo Neya
Torben Pottgiesser
Yorck O Schumacher
Walter F Schmidt

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo characterise the time course of changes in haemoglobin mass (Hbmass) in response to altitude exposure.

methodsThis meta-analysis uses raw data from 17 studies that used carbon monoxide rebreathing to determine Hbmass prealtitude, during altitude and postaltitude. Seven studies were classic altitude training, eight were live high train low (LHTL) and two mixed classic and LHTL. Separate linear-mixed models were fitted to the data from the 17 studies and the resultant estimates of the effects of altitude used in a random effects meta-analysis to obtain an overall estimate of the effect of altitude, with separate analyses during altitude and postaltitude. In addition, within-subject differences from the prealtitude phase for altitude participant and all the data on control participants were used to estimate the analytical SD. The 'true' between-subject response to altitude was estimated from the within-subject differences on altitude participants, between the prealtitude and during-altitude phases, together with the estimated analytical SD.

resultsDuring-altitude Hbmass was estimated to increase by ∼1.1%/100 h for LHTL and classic altitude. Postaltitude Hbmass was estimated to be 3.3% higher than prealtitude values for up to 20 days. The within-subject SD was constant at ∼2% for up to 7 days between observations, indicative of analytical error. A 95% prediction interval for the 'true' response of an athlete exposed to 300 h of altitude was estimated to be 1.1-6%.

conclusionsCamps as short as 2 weeks of classic and LHTL altitude will quite likely increase Hbmass and most athletes can expect benefit.

Indexed as

AltitudeAcclimatizationAthletic PerformanceCarbon MonoxideCarboxyhemoglobinHemoglobinsHumansHypoxiaRespirationCarbon MonoxideCarboxyhemoglobinHemoglobinsAltitudeStatistical review

Identifiers

PMID24282204
PMCPMC3903147

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.