ArticleJournal of biophotonics2015
In vivo pump-probe optical coherence tomography imaging in Xenopus laevis.
Article in Journal of biophotonics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Molecular Contrast Optical Coherence Tomography and Its Applications in Medicine.International journal of molecular sciences · 2022Review
- Methylene blue-filled biodegradable polymer particles as a contrast agent for optical coherence tomography.Biomedical optics express · 2020Article
- In vivo molecular contrast OCT imaging of methylene blue.Optics letters · 2015Article
- Molecular Imaging in Optical Coherence Tomography.Current molecular imaging · 2014Article
- Advances in multimodal imaging in ophthalmology.Therapeutic advances in ophthalmologyReview
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Currently, optical coherence tomography (OCT), is not capable of obtaining molecular information often crucial for identification of disease. To enable molecular imaging with OCT, we have further developed a technique that harnesses transient changes in light absorption in the sample to garner molecular information. A Fourier-domain Pump-Probe OCT (PPOCT) system utilizing a 532 nm pump and 830 nm probe has been developed for imaging hemoglobin. Methylene blue, a biological dye with well-know photophysics, was used to characterize the system before investigating the origin of the hemoglobin PPOCT signal. The first in vivo PPOCT images were recorded of the vasculature in Xenopus laevis. The technique was shown to work equally well in flowing and nonflowing vessels. Furthermore, PPOCT was compared with other OCT extensions which require flow, such as Doppler OCT and phase-variance OCT. PPOCT was shown to better delineate tortuous vessels, where nodes often restrict Doppler and phase-variance reconstruction.
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Registered trials
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