ReviewEndocrine2014
Harmful effects of functional hypercortisolism: a working hypothesis.
Review in Endocrine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Heart Rate Variability and Sympathetic Activity Is Modulated by Very Low-Calorie Ketogenic Diet.International journal of environmental research and public health · 2022Trial
- White adipose tissue expansion as the driver of insulin resistance and secondary endocrine disturbances in obesity- a narrative review.Diabetology & metabolic syndrome · 2026Review
- Article
- Lifestyle in Obese Individuals during the COVID-19 Pandemic.Healthcare (Basel, Switzerland) · 2022Article
- Pathophysiology of Mild Hypercortisolism: From the Bench to the Bedside.International journal of molecular sciences · 2022Review
- Association between self-reported medical diagnosis of depression and metabolic syndrome in a population-based study: A propensity score-matched analysis.Nursing open · 2022Article
- The Role of Very Low Calorie Ketogenic Diet in Sympathetic Activation through Cortisol Secretion in Male Obese Population.Journal of clinical medicine · 2021Article
- Early post-natal life stress induces permanent adrenocorticotropin-dependent hypercortisolism in male mice.Endocrine · 2021Article
- Hypothalamic-Pituitary Diseases and Erectile Dysfunction.Journal of clinical medicine · 2021Review
- A New Clinical Model to Estimate the Pre-Test Probability of Cushing's Syndrome: The Cushing Score.Frontiers in endocrinology · 2021Article
- Reference ranges of late-night salivary cortisol and cortisone measured by LC-MS/MS and accuracy for the diagnosis of Cushing's syndrome.Journal of endocrinological investigation · 2020Article
- Venous thromboembolism in anorexia nervosa: four cases from a specialized unit. Indication for thromboprophylaxis?Eating and weight disorders : EWD · 2020Article
- The diagnostic accuracy of increased late night salivary cortisol for Cushing's syndrome: a real-life prospective study.Journal of endocrinological investigation · 2019Article
- Ocular hypertension secondary to obesity: cortisol, the missing piece of the pathophysiological puzzle?International journal of ophthalmology · 2019Article
- Secondary Arterial Hypertension: From Routine Clinical Practice to Evidence in Patients with Adrenal Tumor.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2018Review
- Common Sleep, Psychiatric, and Somatic Problems According to Work Schedule: an Internet Survey in an Eastern European Country.International journal of behavioral medicine · 2018Article
- High-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology.BMC systems biology · 2018Article
- Lower Renal Function Is Associated With Derangement of 11-Journal of the Endocrine Society · 2018Article
- Stress and Obesity: Are There More Susceptible Individuals?Current obesity reports · 2018Review
- Diabetes in Cushing Disease.Current diabetes reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional hypercortisolism (FH) is caused by conditions able to chronically activate hypothalamic-pituitary-adrenal axis and usually occurs in cases of major depression, anorexia nervosa, bulimia nervosa, alcoholism, diabetes mellitus, simple obesity, polycystic ovary syndrome, obstructive sleep apnea syndrome, panic disorder, generalized anxiety disorder, shift work, and end-stage renal disease. Most of these states belong to pseudo-Cushing disease, a condition which is difficult to distinguish from Cushing's syndrome and characterized not only by biochemical findings but also by objective ones that can be attributed to hypercortisolism (e.g., striae rubrae, central obesity, skin atrophy, easy bruising, etc.). This hormonal imbalance, although reversible and generally mild, could mediate some systemic complications, mainly but not only of a metabolic/cardiovascular nature, which are present in these states and are largely the same as those present in Cushing's syndrome. In this review we aim to discuss the evidence suggesting the emerging negative role for FH.
Indexed as
Identifiers
24282037What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.