ArticleOptics letters2013
Topical dual-stain difference imaging for rapid intra-operative tumor identification in fresh specimens.
Article in Optics letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Evaluating Receptor-Specific Fresh Specimen Staining for Tumor Margin Detection in Clinical Breast Specimens.Molecular imaging and biology · 2023Article
- Dual probe difference specimen imaging for prostate cancer margin assessment.Journal of biomedical optics · 2023Article
- TRIPODD: a Novel Fluorescence Imaging Platform for In Situ Quantification of Drug Distribution and Therapeutic Response.Molecular imaging and biology · 2021Article
- A method for validating depth-resolved biodistributions in topically-stained specimen with multi-channel fluorescence cryo-imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2021Article
- Fluorescent Imaging forProceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Intracellular paired agent imaging enables improved evaluation of tyrosine kinase inhibitor target engagement.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Topical dual-probe staining using quantum dot-labeled antibodies for identifying tumor biomarkers in fresh specimens.PloS one · 2020Article
- Rapid pathology of lumpectomy margins with open-top light-sheet (OTLS) microscopy.Biomedical optics express · 2019Article
- Modeling the binding and diffusion of receptor-targeted nanoparticles topically applied on fresh tissue specimens.Physics in medicine and biology · 2019Article
- Diagnostic Performance of Receptor-Specific Surgical Specimen Staining Correlate with Receptor Expression Level.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Diagnostic performance of receptor-specific surgical specimen staining correlates with receptor expression level.Journal of biomedical optics · 2019Article
- Effect of staining temperature on topical dual stain imaging of tissue specimens for tumor identification.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Light scattering measured with spatial frequency domain imaging can predict stromal versus epithelial proportions in surgically resected breast tissue.Journal of biomedical optics · 2018Article
- Automated detection of breast cancer in resected specimens with fluorescence lifetime imaging.Physics in medicine and biology · 2017Article
- Development and evaluation of a connective tissue phantom model for subsurface visualization of cancers requiring wide local excision.Journal of biomedical optics · 2017Article
- Rinsing paired-agent model (RPAM) to quantify cell-surface receptor concentrations in topical staining applications of thick tissues.Physics in medicine and biology · 2017Article
- Optimizing fresh specimen staining for rapid identification of tumor biomarkers during surgery.Theranostics · 2017Article
- Quantification of the binding potential of cell-surface receptors in fresh excised specimens via dual-probe modeling of SERS nanoparticles.Scientific reports · 2015Article
- Application of Fluorescence-Guided Surgery to Subsurface Cancers Requiring Wide Local Excision: Literature Review and Novel Developments Toward Indirect Visualization.Cancer control : journal of the Moffitt Cancer CenterReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Assessing tumor margin status during surgery is critical to ensure complete resection of cancer tissue; however, current approaches are ineffective and often result in repeat surgery. We present an optical imaging approach for margin assessment using topical application of two fluorescent stains, one targeted to a tumor biomarker and the other a nontargeted reference, to freshly excised specimens. Computing a normalized difference image from fluorescence images of the targeted and untargeted stains suppresses the confounding effects of nonspecific uptake. Applying this approach in excised breast tumor models produced promising tumor-to-normal tissue contrasts that were significantly higher than single-targeted-stain imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.