ReviewJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2014
Evolution of vertebrate mechanosensory hair cells and inner ears: toward identifying stimuli that select mutation driven altered morphologies.
Review in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 116 citations in OpenAlex.
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- Evolutionary tuning of an auditory transduction channel.Current biology : CB · 2026Article
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- Evolutionary modularity of the primate vestibular system: Morphological distinction of otolithic and canalicular organs.PNAS nexus · 2026Article
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- prdm1a drives a fate switch between hair cells of different mechanosensory organs.Nature communications · 2025Article
- Sponge bHLH Gene Expression inInternational journal of molecular sciences · 2025Article
- Novel cVEMP procedure reveals sexual dimorphism in peak to trough latency.Frontiers in integrative neuroscience · 2025Article
- Genomic and single-cell analyses reveal genetic signatures of swimming pattern and diapause strategy in jellyfish.Nature communications · 2024Article
- The origins of light-independent magnetoreception in humans.Frontiers in human neuroscience · 2024Review
- Differential energetic profile of signal processing in central vestibular neurons.Frontiers in neurology · 2024Article
- Gene networks and the evolution of olfactory organs, eyes, hair cells and motoneurons: a view encompassing lancelets, tunicates and vertebrates.Frontiers in cell and developmental biology · 2024Review
- What is it like to be a choanoflagellate? Sensation, processing and behavior in the closest unicellular relatives of animals.Animal cognition · 2023Review
- The evolution of the various structures required for hearing inIBRO neuroscience reports · 2023Article
- Molecular mechanisms governing development of the hindbrain choroid plexus and auditory projection: A validation of the seminal observations of Wilhelm His.IBRO neuroscience reports · 2022Review
- Article
- Hearing without a tympanic ear.The Journal of experimental biology · 2022Review
- GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor.Scientific reports · 2022Article
- Early Deletion ofFrontiers in cell and developmental biology · 2022Article
- Development and evolution of the vestibular apparatuses of the inner ear.Journal of anatomy · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Among the major distance senses of vertebrates, the ear is unique in its complex morphological changes during evolution. Conceivably, these changes enable the ear to adapt toward sensing various physically well-characterized stimuli. This review develops a scenario that integrates sensory cell with organ evolution. We propose that molecular and cellular evolution of the vertebrate hair cells occurred prior to the formation of the vertebrate ear. We previously proposed that the genes driving hair cell differentiation were aggregated in the otic region through developmental re-patterning that generated a unique vertebrate embryonic structure, the otic placode. In agreement with the presence of graviceptive receptors in many vertebrate outgroups, it is likely that the vertebrate ear originally functioned as a simple gravity-sensing organ. Based on the rare occurrence of angular acceleration receptors in vertebrate outgroups, we further propose that the canal system evolved with a more sophisticated ear morphogenesis. This evolving morphogenesis obviously turned the initial otocyst into a complex set of canals and recesses, harboring multiple sensory epithelia each adapted to the acquisition of a specific aspect of a given physical stimulus. As support for this evolutionary progression, we provide several details of the molecular basis of ear development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.