Evidence map›Paper›PMID 24281251›Full record

SynthesisEuropean journal of preventive cardiology2015

Increased cardiovascular mortality associated with gout: a systematic review and meta-analysis.

L E Clarson, P Chandratre, S L Hider, J Belcher, C Heneghan, E Roddy, C D Mallen

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of preventive cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  16. Gout, Uric Acid, and Coronary Artery Disease.Journal of atherosclerosis and thrombosis · 2025
    Review
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

L E ClarsonKeele University, Keele, UK l.clarson@keele.ac.uk.
P ChandratreKeele University, Keele, UK.
S L HiderKeele University, Keele, UK.
J BelcherKeele University, Keele, UK.
C HeneghanOxford University, Oxford, UK.
E RoddyKeele University, Keele, UK.
C D MallenKeele University, Keele, UK.

Funding

Versus Arthritis 19634
6 · The paper itself

Abstract

backgroundHyperuricaemia, the biochemical precursor to gout, has been shown to be an independent risk factor for mortality from cardiovascular disease (CVD), although studies examining the clinical phenomenon of gout and risk of CVD mortality report conflicting results. This study aimed to produce a pooled estimate of risk of mortality from cardiovascular disease in patients with gout.

designSystematic review and meta-analysis.

methodsElectronic bibliographic databases were searched from inception to November 2012, with results reviewed by two independent reviewers. Studies were included if they reported data on CVD mortality in adults with gout who were free of CVD at time of entry into the study. Pooled hazard ratios (HRs) for this association were calculated both unadjusted and adjusted for traditional vascular risk factors.

resultsSix papers, including 223,448 patients, were eligible for inclusion (all (CVD) mortality n = 4, coronary heart disease (CHD) mortality n = 3, and myocardial infarction mortality n = 3). Gout was associated with an excess risk of CVD mortality (unadjusted HR 1.51 (95% confidence interval, CI, 1.17-1.84)) and CHD mortality (unadjusted HR 1.59, 95% CI 1.25-1.94)). After adjusting for traditional vascular risk factors, the pooled HR for both CVD mortality (HR 1.29, 95% CI 1.14-1.44) and CHD mortality (HR 1.42, 95% CI 1.22-1.63) remained statistically significant, but none of the studies reported a significant association with myocardial infarction.

conclusionsGout increases the risk of mortality from CVD and CHD, but not myocardial infarction, independently of vascular risk factors.

Indexed as

Cardiovascular DiseasesCause of DeathCoronary DiseaseGoutHumansOdds RatioPrognosisRisk AssessmentRisk FactorsTime FactorsCardiovascular diseasecoronary heart diseasegoutmortalitymyocardial infarction

Identifiers

PMID24281251
PMCPMC4361356

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.