ArticleCancers2010
Aberrant crypt foci: the case for inclusion as a biomarker for colon cancer.
Article in Cancers, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Optimization of DMH-Induced Colorectal Carcinogenesis in Rats: A Systematic Meta-Review.Clinical and experimental gastroenterology · 2026Review
- Bifidobacterium lactis ameliorates AOM/DSS-induced inflammation, dysbiosis, and colonic precancerous lesions.Applied microbiology and biotechnology · 2025Article
- Article
- Characterization of Extractable and Non-Extractable Phenols and Betalains in Berrycactus (Antioxidants (Basel, Switzerland) · 2024Article
- Panx1 knockout promotes preneoplastic aberrant crypt foci development in a chemically induced model of mouse colon carcinogenesis.International journal of experimental pathology · 2023Article
- The role of TNF-α and NFkβ in an experimental model of intestinal carcinogenesis with 1,2-dimethyhydrazine.Acta cirurgica brasileira · 2023Article
- The Implications of Connexin 43 Deficiency during the Early Stages of Chemically Induced Mouse Colon Carcinogenesis.Antioxidants (Basel, Switzerland) · 2022Article
- Inhibitory Effect of Dietary Defatted Rice Bran in an AOM/DSS-Induced Colitis-Associated Colorectal Cancer Experimental Animal Model.Foods (Basel, Switzerland) · 2022Article
- Mouse Models for Application in Colorectal Cancer: Understanding the Pathogenesis and Relevance to the Human Condition.Biomedicines · 2022Review
- 3D cyclorama for digital unrolling and visualisation of deformed tubes.Scientific reports · 2021Article
- Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Synbiotic Combination of Djulis (Nutrients · 2019Article
- Evaluation of immunologic and intestinal effects in rats administered an E 171-containing diet, a food grade titanium dioxide (TiOFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2019Article
- Article
- Pectin-encrusted gold nanocomposites containing phytic acid and jacalin: 1,2-dimethylhydrazine-induced colon carcinogenesis in Wistar rats, PI3K/Akt, COX-2, and serum metabolomics as potential targets.Drug delivery and translational research · 2019Article
- Hypotheses on the Potential of Rice Bran Intake to Prevent Gastrointestinal Cancer through the Modulation of Oxidative Stress.International journal of molecular sciences · 2017Review
- Protective Effect of Lactobacillus casei on DMH-Induced Colon Carcinogenesis in Mice.Probiotics and antimicrobial proteins · 2017Article
- Role of neutral ceramidase in colon cancer.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Hesperidin alleviates oxidative stress and downregulates the expressions of proliferative and inflammatory markers in azoxymethane-induced experimental colon carcinogenesis in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. In this review, we critically present the molecular, cellular, histopathological, and chemopreventive evidence that ACF are relevant biomarkers for colon cancer. The laboratory and clinical evidence are highly suggestive that ACF are in the pathway leading to colon cancer, but not all ACF will do so. The possible fate and outcome of ACF in the progression toward colon cancer may be dependent on a number of features that define their predictive power for the prevention or progression of cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.