ArticleCancers2010
Oxidative stress induced mechanisms in the progression of periodontal diseases and cancer: a common approach to redox homeostasis?
Article in Cancers, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Causal association between periodontitis and systemic diseases: a systematic review and meta-analysis of mendelian randomization studies.BMC oral health · 2026Pooled it
- Oral health and risk of colorectal cancer: results from three cohort studies and a meta-analysis.Annals of oncology : official journal of the European Society for Medical Oncology · 2016Pooled it
- Relationship between the risk of breast cancer and periodontal disease: a case-control study.Scientific reports · 2025Article
- Head and neck cancer patients show poor oral health as compared to those with other types of cancer.BMC oral health · 2023Article
- Reactive Oxygen Species Enlightened Therapeutic Strategy for Oral and Maxillofacial Diseases-Art of Destruction and Reconstruction.Biomedicines · 2022Review
- Two-Sample Mendelian Randomization Analysis of Associations Between Periodontal Disease and Risk of Cancer.JNCI cancer spectrum · 2021Article
- Quantitative Estimation of Oxidative Stress in Cancer Tissue Cells Through Gene Expression Data Analyses.Frontiers in genetics · 2020Article
- Nuclear morphological changes in gingival epithelial cells of patients with periodontitis.Clinical oral investigations · 2019Article
- Relationship between the nutritional status and antimicrobial protein levels with the periodontal condition in untreated head and neck cancer patients.Journal of family medicine and primary care · 2019Article
- Periodontitis as a risk factor for lung cancer among women: A nationwide matched cohort study.The Kaohsiung journal of medical sciences · 2019Article
- Risk of colorectal cancer in patients with periodontal disease severity: a nationwide, population-based cohort study.International journal of colorectal disease · 2018Article
- Oxidative Stress in Oral Diseases: Understanding Its Relation with Other Systemic Diseases.Frontiers in physiology · 2017Review
- Chronic Periodontitis in Type 2 Diabetes Mellitus: Oxidative Stress as a Common Factor in Periodontal Tissue Injury.Journal of clinical and diagnostic research : JCDR · 2016Article
- Periodontal Disease and Breast Cancer: Prospective Cohort Study of Postmenopausal Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Observational
- MIEN1 promotes oral cancer progression and implicates poor overall survival.Cancer biology & therapy · 2015Article
- LPS from P. gingivalis and hypoxia increases oxidative stress in periodontal ligament fibroblasts and contributes to periodontitis.Mediators of inflammation · 2014Article
- Links demystified: Periodontitis and cancer.Dental research journal · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is documented evidence of significant associations between cancer of the lung, kidney, pancreas, hematological and oral cancers and periodontal diseases of the supporting structures of the teeth. Enhanced lipid peroxidation, raised levels of TBARS and the oxidative stress marker malondealdehyde have been detected in breast cancer with reduced antioxidant capacity, also characteristic of periodontal diseases. Antioxidants could overcome this deficit and attenuate disease progression by down regulating glutathione detoxification/redox buffering system and inhibiting key transcription factors. Periodontal disease may be a critical marker of a susceptible immune system, or initiate cancer risk with a pro-oxidant inflammatory profile.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.