ReviewMolecular psychiatry2014
A model for streamlining psychotherapy in the RDoC era: the example of 'Engage'.
Review in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed.
- Brain Activation Associated With Response to Psychotherapies for Late-Life Depression: A Task-Based fMRI Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Trial
- Modifiable predictors of suicidal ideation during psychotherapy for late-life major depression. A machine learning approach.Translational psychiatry · 2021Trial
- Modifiable predictors of nonresponse to psychotherapies for late-life depression with executive dysfunction: a machine learning approach.Molecular psychiatry · 2021Trial
- Comparing the streamlined psychotherapy "Engage" with problem-solving therapy in late-life major depression. A randomized clinical trial.Molecular psychiatry · 2021Trial
- A Pilot Randomized Trial of Engage Psychotherapy to Increase Social Connection and Reduce Suicide Risk in Later Life.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Trial
- Resting State Functional Connectivity and Outcomes of Psychotherapies for Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020Trial
- Engagement in Socially and Interpersonally Rewarding Activities as a Predictor of Outcome in "Engage" Behavioral Activation Therapy for Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Trial
- Comparing engage with PST in late-life major depression: a preliminary report.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2015Trial
- Smartphone-Based Passive Sensing of Activity Levels and Behavioral Activation During Psychosocial Interventions for Older Adults With Depression: Longitudinal Observational Study.Journal of medical Internet research · 2026Observational
- Targeting mechanisms of change as a path to precision psychotherapy for community settings.Psychotherapy research : journal of the Society for Psychotherapy Research · 2026Article
- Improving Adherence to Psychotherapy and Clinical Outcome in Patients With Late-Life Depression Through Gamified mHealth Technology.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Pilot Study of Behavioral Activation Treatment for Negative Symptoms in Older Adults With Schizophrenia Spectrum Disorder.Psychiatric research and clinical practice · 2026Article
- Engage & connect psychotherapy improves social reward responsivity and reduces postpartum depression.Psychotherapy research : journal of the Society for Psychotherapy Research · 2025Article
- Relation Between Executive Function Test Performance and Treatment Outcomes During Brief Psychotherapies for Later-Life Depression.The American journal of geriatric psychiatry. Open science, education, and practice · 2025Article
- Distinct Computational Mechanisms of Uncertainty Processing Explain Opposing Exploratory Behaviors in Anxiety and Apathy.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Reducing Depression and Suicidal Ideation Among Elder Abuse Victims Using PROTECT.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Article
- Increasing Completion of Daily Patient-Reported Outcomes in Psychotherapies for Late-Life Depression through User-Centered Design.Applied clinical informatics · 2024Article
- Improving social reward responsivity and social connectedness in psychotherapies for late-life depression: Engage & Connect as an example.Psychiatry research · 2023Article
- Biological factors influencing depression in later life: role of aging processes and treatment implications.Translational psychiatry · 2023Review
- A Pilot Study of Brief, Stepped Behavioral Activation for Primary Care Patients with Depressive Symptoms.Journal of clinical psychology in medical settings · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A critical task for psychotherapy research is to create treatments that can be used by community clinicians. Streamlining of psychotherapies is a necessary first step for this purpose. We suggest that neurobiological knowledge has reached the point of providing biologically meaningful behavioral targets, thus guiding the development of effective, simplified psychotherapies. This view is supported by the Research Domain Criteria (RDoC) Project, which reflects the field's consensus and recognizes the readiness of neurobiology to guide research in treatment development. 'Engage' is an example of such a streamlined therapy. It targets behavioral domains of late-life depression grounded on RDoC constructs using efficacious behavioral strategies selected for their simplicity. 'Reward exposure' targeting the behavioral expression of positive valence systems' dysfunction is the principal therapeutic vehicle of 'Engage'. Its first three sessions consist of direct 'reward exposure', but the therapists search for barriers in three behavioral domains, that is, 'negativity bias' (negative valence), 'apathy' (arousal) and 'emotional dysregulation' (cognitive control), and add strategies targeting these domains when needed. The end result is a structured, stepped approach using neurobiological constructs as targets and as a guide to personalization. We argue that the 'reduction' process needed in order to arrive to simplified effective therapies can be achieved in three steps: (1) identify RDoC constructs driving the syndrome's psychopathology; (2) create a structured intervention utilizing behavioral and ecosystem modification techniques targeting behaviors related to these constructs; (3) examine whether the efficacy of the new intervention is mediated by change in behaviors related to the targeted RDoC constructs.
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