Trial reportKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2015
Healing of donor site in bone-tendon-bone ACL reconstruction accelerated with plasma rich in growth factors: a randomized clinical trial.
Trial report in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 43 citations in OpenAlex.
- Role of Platelet-Rich Plasma Injection in Anterior Cruciate Ligament Reconstruction: A Meta-Analysis of Randomized Controlled Trials.Bioengineering (Basel, Switzerland) · 2026Article
- Platelet-Rich Plasma in Anterior Cruciate Ligament Reconstruction: An Updated Systematic Review and Meta-Analysis of Clinical and Radiological Outcomes.Journal of clinical medicine · 2026Review
- Indications, Techniques, and Outcomes of Bridge-Enhanced ACL Restoration (BEAR).Current reviews in musculoskeletal medicine · 2025Review
- Evaluation of Serum Albumin-Coated Bone Allograft for Bone Regeneration: A Seven-Year Follow-Up Study of 26 Cases.International journal of molecular sciences · 2023Article
- Histological and biochemical evaluation of plasma rich in growth factors treatment for grade II muscle injuries in sheep.BMC veterinary research · 2022Article
- ACL Reconstruction with Augmentation: a Scoping Review.Current reviews in musculoskeletal medicine · 2019Article
- Enhanced tendon-bone healing with acidic fibroblast growth factor delivered in collagen in a rabbit anterior cruciate ligament reconstruction model.Journal of orthopaedic surgery and research · 2018Article
- The non-reconstructive treatment of complete ACL tear with biological enhancement in clinical and preclinical studies: A systematic review.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2018Review
- Advances in anterior cruciate ligament reconstruction techniques.Annals of translational medicine · 2016Article
- Bone-Albumin filling decreases donor site morbidity and enhances bone formation after anterior cruciate ligament reconstruction with bone-patellar tendon-bone autografts.International orthopaedics · 2016Article
- Partial anterior cruciate ligament tears treated with intraligamentary plasma rich in growth factors.World journal of orthopedics · 2014Article
- Anterior knee pain in ACL reconstruction with BPTB graft - Is it a myth? Comparative outcome analysis with hamstring graft in 1,250 patients.Journal of orthopaedicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine whether the use of plasma rich in growth factors accelerates healing of the donor site in bone-tendon-bone anterior cruciate ligament (ACL) reconstruction (patellar graft). The use of the patellar graft presents post-operative problems such as anterior knee pain, which limits its use and leads to preference being taken for alternative grafts.
methodsA double-blind, randomized, clinical trial was performed comparing two groups of patients who underwent ACL reconstruction using patellar tendon graft and comparing the use of plasma rich in growth factors at the donor site after graft harvest in terms of local regeneration by ultrasound assessment.
resultsThe plasma rich in growth factors group shows earlier donor site regeneration in comparison with the control group (2 months earlier), with significant differences in the first 4 months of the follow-up.
conclusionThe application of plasma rich in growth factors shows accelerated tissue regeneration processes with respect to the control group. This fact, together with the previously published with similar conclusions, can create a knowledge basis in order to set out new recovery guidelines following ACL reconstruction. LEVEL OF EVIDENCE: Therapeutic study, Level I.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.