ArticleInflammatory bowel diseases2014
Patient preferences for surgical versus medical therapy for ulcerative colitis.
Article in Inflammatory bowel diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Patient Perspectives and Expectations in Inflammatory Bowel Disease: A Systematic Review.Digestive diseases and sciences · 2022Pooled it
- Discrete Choice Experiments in Health Economics: Past, Present and Future.PharmacoEconomics · 2019Pooled it
- Health State Utility Values for Ileostomies and Colostomies: a Systematic Review and Meta-Analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Pooled it
- What are patients' preferences for revision surgery after periprosthetic joint infection? A discrete choice experiment.BMJ open · 2020Trial
- Beyond the Average: Modeling Individual-Specific Preferences for Ulcerative Colitis Surgery.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2026Article
- Understanding Patient and Gastroenterologist Preferences at the Time of Treatment Escalation to First-Line Advanced Therapy in Ulcerative Colitis: A Discrete Choice Experiment in Five European Countries.United European gastroenterology journal · 2026Article
- Real-world patient characteristics, treatments, and outcomes during and after severe ulcerative colitis hospitalization.Journal of Crohn's & colitis · 2026Article
- Benefit-Risk Trade-offs and Patient Preferences for Therapy Selection in Ulcerative Colitis: a Multicountry Preference Study.Inflammatory bowel diseases · 2025Article
- Patient and Healthcare Professional Perspectives on Crohn's Perianal Fistula Treatment: Results From a Discrete Choice Experiment.Crohn's & colitis 360 · 2025Article
- Understanding the Perspectives and Experiences of Patients with Acute Severe Ulcerative Colitis in the Hospital: A Qualitative Analysis.Digestive diseases and sciences · 2024Article
- Analyzing Google Search Trends for Migraine Surgery and Nurtec in Response to Public Announcements.Plastic and reconstructive surgery. Global open · 2024Article
- Patient preferences and current practice for adults with steroid-resistant ulcerative colitis: POPSTER mixed-methods study.Health technology assessment (Winchester, England) · 2022Article
- Modeling Optimal Clinical Thresholds for Elective Abdominal Hernia Repair in Patients With Cirrhosis.JAMA network open · 2022Article
- Women's Willingness to Accept Risks of Medication for Inflammatory Bowel Disease During Pregnancy.The patient · 2022Article
- Acute Severe Colitis: The Need for Joint Management between Gastroenterologists and Surgeons.Clinics in colon and rectal surgery · 2022Review
- Optimal Placement of Colectomy in the Treatment of Ulcerative Colitis: a Markov Model Analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Inpatient Therapy With Calcineurin Inhibitors in Severe Ulcerative Colitis.Inflammatory bowel diseases · 2021Article
- Development and Feasibility of a Web-Based Decision Aid for Patients With Ulcerative Colitis: Qualitative Pilot Study.Journal of medical Internet research · 2021Article
- A Qualitative Research for Defining Meaningful Attributes for the Treatment of Inflammatory Bowel Disease from the Patient Perspective.The patient · 2020Article
- AGA Technical Review on the Management of Moderate to Severe Ulcerative Colitis.Gastroenterology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTherapy options for mesalamine-refractory ulcerative colitis (UC) include immunosuppressive medications or surgery. Chronic immunosuppressive therapy increases risks of infection and cancer, whereas surgery produces a permanent change in bowel function. We sought to quantify the willingness of patients with UC to accept the risks of chronic immunosuppression to avoid colectomy.
methodsWe conducted a state-of-the-art discrete-choice experiment among 293 patients with UC who were offered a choice of medication or surgical treatments with different features. Random parameters logit was used to estimate patients' willingness to accept trade-offs among treatment features in selecting surgery versus medical treatment.
resultsA desire to avoid surgery and the surgery type (ostomy versus J-pouch) influenced patients' choices more than a specified range of 10-year mortality risks from lymphoma or infection, or disease activity (mild versus remission). To avoid an ostomy, patients were willing to accept a >5% 10-year risk of dying from lymphoma or infection from medical therapy, regardless of medication efficacy. However, data on patients' stated choice indicated perceived equivalence between J-pouch surgery and incompletely effective medical therapy. Patient characteristics and disease history influenced patients' preferences regarding surgery versus medical therapy.
conclusionsPatients with UC are willing to accept relatively high risks of fatal complications from medical therapy to avoid a permanent ostomy and to achieve durable clinical remission. However, patients view J-pouch surgery, but not permanent ileostomy, as an acceptable therapy for refractory UC in which medical therapy is unable to induce a durable remission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.