Evidence map›Paper›PMID 24280768›Full record

SynthesisGut microbes

What do we know about benefits of H. pylori treatment in childhood?

Mónica S Sierra, Emily V Hastings, Karen J Goodman

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Global Profile of Drug Resistance Related toHealth science reports · 2025
    Review
  2. Clinical Dilemmas for the Diagnosis and Treatment ofPediatric gastroenterology, hepatology & nutrition · 2024
    Review
  3. Gastroenterology & hepatology · 2024
    Article
  4. Impact ofDiagnostics (Basel, Switzerland) · 2023
    Review
  5. Treatment of PediatricAntibiotics (Basel, Switzerland) · 2022
    Review
  6. Article
  7. Article
  8. Journal of clinical medicine · 2020
    Article
  9. International journal of pediatrics · 2020
    Article
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mónica S SierraCentre of Excellence for Gastrointestinal Inflammation and Immunity Research; Department of Medicine; Department of Public Health Sciences; School of Public Health; University of Alberta; Edmonton, AB Canada.
Emily V HastingsCentre of Excellence for Gastrointestinal Inflammation and Immunity Research; Department of Medicine; Department of Public Health Sciences; School of Public Health; University of Alberta; Edmonton, AB Canada.
Karen J GoodmanCentre of Excellence for Gastrointestinal Inflammation and Immunity Research; Department of Medicine; Department of Public Health Sciences; School of Public Health; University of Alberta; Edmonton, AB Canada.
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Policy analysis shows that H. pylori test and treat strategies targeting adults at moderate to high risk of H. pylori-induced disease is likely to be cost-effective for preventing digestive diseases responsible for a large global disease burden. Little is known, however, about health benefits to children from eliminating this infection. We conducted a systematic review of the evidence regarding health benefits to children from treatment to eliminate H. pylori infection.   We systematically searched Ovid MEDLINE for pertinent review articles published through 2012. We excluded reviews focused on treatment efficacy and scrutinized reference lists of selected reviews to identify additional eligible reviews. Fifteen reviews met specified inclusion criteria. Overall, they show that few reported studies investigating pediatric health effects of treatment for H. pylori infection were well designed with adequate statistical power. Thus, there is insufficient evidence for drawing conclusions about health benefits to children from treatment to eliminate H. pylori infection.

Indexed as

Helicobacter pyloriAnemia, Iron-DeficiencyChildClinical Trials as TopicGastroesophageal RefluxGrowth DisordersHelicobacter InfectionsHumansMeta-Analysis as TopicPurpura, Thrombocytopenic, IdiopathicbenefitchildHelicobacter pyloripreventiontreatment

Identifiers

PMID24280768
PMCPMC3928165
OpenAlexW1966463482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.