ArticleJournal of biomechanics2014
Biomechanical and structural response of healing Achilles tendon to fatigue loading following acute injury.
Article in Journal of biomechanics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
48 citing papers in PubMed, 72 citations in OpenAlex.
- Effects of Mechanical Loading on the Structure and Function of the Achilles Tendon: From Homeostatic Adaptation to Pathological Degeneration.Journal of functional morphology and kinesiology · 2026Review
- Extrinsic Factors Contributing to Achilles Tendon Ruptures During NFL Games From 2010-2023: A Retrospective Analysis.Orthopaedic journal of sports medicine · 2026Article
- Muscle Contraction Is Essential for Tendon Healing and Muscle Function Recovery After Achilles Tendon Rupture and Surgical Repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Moderate- and High-Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- In Vivo Photoacoustic Ultrasound (PAUS) Assay for Monitoring Tendon Collagen Compositional Changes during Injury and Healing.Diagnostics (Basel, Switzerland) · 2024Article
- Evaluation of tendon and ligament microstructure and mechanical properties in a canine model of mucopolysaccharidosis I.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Novel bisphosphonate-based cathepsin K-triggered compound targets the enthesis without impairing soft tissue-to-bone healing.Frontiers in bioengineering and biotechnology · 2024Article
- Role of hierarchy structure on the mechanical adaptation of self-healing hydrogels under cyclic stretching.Science advances · 2023Article
- Global trends in research of achilles tendon injury/rupture: A bibliometric analysis, 2000-2021.Frontiers in surgery · 2023Article
- Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity.Nature biomedical engineering · 2022Article
- Nonsurgical treatment reduces tendon inflammation and elevates tendon markers in early healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Axin2-lineage cells contribute to neonatal tendon regeneration.Connective tissue research · 2022Article
- Aging and matrix viscoelasticity affect multiscale tendon properties and tendon derived cell behavior.Acta biomaterialia · 2022Article
- Method development and characterization of chick embryo tendon mechanical properties.Journal of biomechanics · 2022Article
- Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon.Cell death & disease · 2021Article
- A numerical framework for mechano-regulated tendon healing-Simulation of early regeneration of the Achilles tendon.PLoS computational biology · 2021Article
- Polydeoxyribonucleotide Ameliorates Inflammation and Apoptosis in Achilles Tendon-Injury Rats.International neurourology journal · 2020Article
- Microsurgical reconstruction affects the outcome in a translational mouse model for Achilles tendon healing.Journal of orthopaedic translation · 2020Article
- Effects of Pulsed Electromagnetic Field Therapy on Rat Achilles Tendon Healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Quadriceps and Patellar Tendon Thickness and Stiffness in Elite Track Cyclists: An Ultrasonographic and Myotonometric Evaluation.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Achilles tendon injuries affect both athletes and the general population, and their incidence is rising. In particular, the Achilles tendon is subject to dynamic loading at or near failure loads during activity, and fatigue induced damage is likely a contributing factor to ultimate tendon failure. Unfortunately, little is known about how injured Achilles tendons respond mechanically and structurally to fatigue loading during healing. Knowledge of these properties remains critical to best evaluate tendon damage induction and the ability of the tendon to maintain mechanical properties with repeated loading. Thus, this study investigated the mechanical and structural changes in healing mouse Achilles tendons during fatigue loading. Twenty four mice received bilateral full thickness, partial width excisional injuries to their Achilles tendons (IACUC approved) and twelve tendons from six uninjured mice were used as controls. Tendons were fatigue loaded to assess mechanical and structural properties simultaneously after 0, 1, 3, and 6 weeks of healing using an integrated polarized light system. Results showed that the number of cycles to failure decreased dramatically (37-fold, p<0.005) due to injury, but increased throughout healing, ultimately recovering after 6 weeks. The tangent stiffness, hysteresis, and dynamic modulus did not improve with healing (p<0.005). Linear regression analysis was used to determine relationships between mechanical and structural properties. Of tendon structural properties, the apparent birefringence was able to best predict dynamic modulus (R(2)=0.88-0.92) throughout healing and fatigue life. This study reinforces the concept that fatigue loading is a sensitive metric to assess tendon healing and demonstrates potential structural metrics to predict mechanical properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.