ArticleThe Journal of biological chemistry2014
Interleukin-4 induces up-regulation of endothelial cell claudin-5 through activation of FoxO1: role in protection from complement-mediated injury.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Claudin-2 enhances human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells by modulating antibody binding and complement activation.Frontiers in immunology · 2025Article
- GDNF and cAMP significantly enhanceHeliyon · 2024Article
- Interleukin-4 receptor alpha signaling regulates monocyte homeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Lack of adducin impairs the stability of endothelial adherens and tight junctions and may be required for cAMP-Rac1-mediated endothelial barrier stabilization.Scientific reports · 2022Article
- Human IL-17 and TNF-α Additively or Synergistically Regulate the Expression of Proinflammatory Genes, Coagulation-Related Genes, and Tight Junction Genes in Porcine Aortic Endothelial Cells.Frontiers in immunology · 2022Article
- Cellular reactions in capillary and venous blood in northerners to a short-term period in a climatic chamber.Immunity, inflammation and disease · 2020Article
- TNF-α promotes human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells through downregulating P38-mediated Occludin expression.Cell communication and signaling : CCS · 2019Article
- The complex functioning of the complement system in xenotransplantation.Xenotransplantation · 2019Review
- Claudin-5: gatekeeper of neurological function.Fluids and barriers of the CNS · 2019Review
- A Single-Cell Transcriptome Atlas of the Mouse Glomerulus.Journal of the American Society of Nephrology : JASN · 2018Article
- VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression.Circulation research · 2018Article
- Interleukin-4 and interferon-γ orchestrate an epithelial polarization in the airways.Mucosal immunology · 2016Article
- CD31 signals confer immune privilege to the vascular endothelium.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction--a novel mechanism for maintaining vascular function.Journal of hematology & oncology · 2014Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Injury to endothelial cells (ECs) often results in cell retraction and gap formation. When caused by antigen aggregation or complement, this injury can be prevented by pretreatment of the ECs with IL-4, suggesting that IL-4 modifies the intercellular junction. Therefore, we investigated the effects of IL-4 on expression of intercellular junction proteins and whether such effects are required for IL-4-induced resistance of ECs against complement-mediated injury. We found that IL-4 induces upregulation of the junction protein claudin-5 in porcine ECs through activation of Jak/STAT6 and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm. Increased claudin-5 expression resulted in increased transmembrane electrical resistance of the endothelial monolayer and participated in IL-4-induced protection of the ECs from complement injury. Down-regulation of FoxO1 using siRNA by itself caused up-regulation of claudin-5 expression and partial protection from cytotoxicity. This protection was enhanced by stimulation with IL-4. We previously reported that increased phospholipid synthesis and mitochondrial protection were required for IL-4-induced resistance of ECs against complement injury and now we demonstrate a contribution of claudin-5 expression in IL-4-induced protection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.