ArticleDevelopmental cognitive neuroscience2014
Loss aversion and 5HTT gene variants in adolescent anxiety.
Article in Developmental cognitive neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The Genetics of Risk Aversion: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Neural response to monetary incentives in acquired adolescent depression after mild traumatic brain injury: Stage 2 Registered Report.Brain communications · 2024Article
- The Effects of Citalopram and Thalamic Dopamine DPsychiatry journal · 2022Article
- Brain and Behavior Correlates of Risk Taking in Pediatric Anxiety Disorders.Biological psychiatry · 2021Review
- Threat or thrill? the neural mechanisms underlying the development of anxiety and risk taking in adolescence.Developmental cognitive neuroscience · 2020Article
- Association of Loss Aversion, Personality Traits, Depressive, Anxious, and Suicidal Symptoms: Systematic Review.Clinical neuropsychiatry · 2020Article
- Diminished Value Discrimination in Obsessive-Compulsive Disorder: A Prospect Theory Model of Decision-Making Under Risk.Frontiers in psychiatry · 2019Article
- Risk-seeking for losses is associated with 5-HTTLPR, but not with transient changes in 5-HT levels.Psychopharmacology · 2018Article
- Enhanced Risk Aversion, But Not Loss Aversion, in Unmedicated Pathological Anxiety.Biological psychiatry · 2017Article
- Genetic variation of dopamine and serotonin function modulates the feedback-related negativity during altruistic punishment.Scientific reports · 2017Article
- Increased Loss Aversion in Unmedicated Patients with Obsessive-Compulsive Disorder.Frontiers in psychiatry · 2017Article
- Negative Social Relationships Predict Posttraumatic Stress Symptoms Among War-Affected Children Via Posttraumatic Cognitions.Journal of abnormal child psychology · 2016Article
- Anxiety promotes memory for mood-congruent faces but does not alter loss aversion.Scientific reports · 2016Article
- Emotion-induced loss aversion and striatal-amygdala coupling in low-anxious individuals.Social cognitive and affective neuroscience · 2016Article
- Re-defininG AddiC(CH3)Tion: genomics and epigenomics on substance use disorders.Molecular genetics & genomic medicine · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Loss aversion, a well-documented behavioral phenomenon, characterizes decisions under risk in adult populations. As such, loss aversion may provide a reliable measure of risky behavior. Surprisingly, little is known about loss aversion in adolescents, a group who manifests risk-taking behavior, or in anxiety disorders, which are associated with risk-avoidance. Finally, loss aversion is expected to be modulated by genotype, particularly the serotonin transporter (SERT) gene variant, based on its role in anxiety and impulsivity. This genetic modulation may also differ between anxious and healthy adolescents, given their distinct propensities for risk taking. The present work examines the modulation of loss aversion, an index of risk-taking, and reaction-time to decision, an index of impulsivity, by the serotonin-transporter-gene-linked polymorphisms (5HTTLPR) in healthy and clinically anxious adolescents. Findings show that loss aversion (1) does manifest in adolescents, (2) does not differ between healthy and clinically anxious participants, and (3), when stratified by SERT genotype, identifies a subset of anxious adolescents who are high SERT-expressers, and show excessively low loss-aversion and high impulsivity. This last finding may serve as preliminary evidence for 5HTTLPR as a risk factor for the development of comorbid disorders associated with risk-taking and impulsivity in clinically anxious adolescents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.