ArticleExperimental dermatology2013
Is Mc1r an important regulator of non-pigmentary responses to UV radiation?
Article in Experimental dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NHEuropean journal of medicinal chemistry · 2018Article
- Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation.Journal of medicinal chemistry · 2017Article
- Acerola (Malpighia emarginata DC.) Juice Intake Suppresses UVB-Induced Skin Pigmentation in SMP30/GNL Knockout Hairless Mice.PloS one · 2017Article
- Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes.Molecular and cellular endocrinology · 2016Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
MC1R is recognized for its role in the regulation of melanin pigmentation. In addition, many investigators believe that it also plays a crucial role in immunomodulation (immunosuppression) and in melanogenesis-independent protective responses against ultraviolet radiation (UVR). Surprisingly, Wolnicka-Glubisz et al. have shown that loss of function in the MC1R has no effect on inflammatory responses and immunosuppression induced by UVR in C57BL/6 mice as well as on the degree of UVA-induced DNA damage in the epidermis and dermis. These findings, by challenging the existing dogmas on the precise role of MC1R in non-pigmentary responses to the UVR, mandate further research to either validate the presented data or to define to which degree these phenomena are restricted to the C57BL/6 mouse model or are applicable to other species including humans. The alternative target for immunomodulation is represented by MC3R. However, cutaneous expression of MC3R remains to be demonstrated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.