ArticleParticle and fibre toxicology2013
In utero and early life exposure to diesel exhaust air pollution increases adult susceptibility to heart failure in mice.
Article in Particle and fibre toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Breathing in harm: current insights into the effects of air pollution on cardiorespiratory health.Medical gas research · 2027Review
- Gestational exposure to micro and nanoplastics differentially impacts cardiac development and function in male and female rats throughout the lifespan.Toxicology and applied pharmacology · 2025Article
- Immune consequences of exposure to β-pinene oxidation aerosols: adult versus gestational murine models.Particle and fibre toxicology · 2025Article
- Environmental pollutants and atherosclerosis: Epigenetic mechanisms linking genetic risk and disease.Atherosclerosis · 2025Review
- Short-Term Effects of Low-Level Ambient Air NOInternational journal of environmental research and public health · 2022Article
- Oral administration of TiOParticle and fibre toxicology · 2022Article
- Association between particulate matter air pollution and heart attacks in San Diego County.Journal of the Air & Waste Management Association (1995) · 2021Article
- Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation.Scientific reports · 2021Article
- Cutaneous Effects of In Utero and Lactational Exposure of C57BL/6J Mice to 2,3,7,8-Tetrachlorodibenzo-Toxics · 2021Article
- Air pollution and children's health-a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter.Environmental health and preventive medicine · 2021Review
- Hypothalamic-pituitary-adrenal axis mediates ambient PMEcotoxicology and environmental safety · 2021Article
- Article
- Developmental exposure to diesel exhaust upregulates transcription factor expression, decreases hippocampal neurogenesis, and alters cortical lamina organization: relevance to neurodevelopmental disorders.Journal of neurodevelopmental disorders · 2020Article
- Exposure to fine particulate matter induces self-recovery and susceptibility of oxidative stress and inflammation in rat lungs.Environmental science and pollution research international · 2020Article
- Urban-Related Environmental Exposures during Pregnancy and Placental Development and Preeclampsia: a Review.Current hypertension reports · 2020Review
- Adverse organogenesis and predisposed long-term metabolic syndrome from prenatal exposure to fine particulate matter.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Prenatal and early life diesel exhaust exposure disrupts cortical lamina organization: Evidence for a reelin-related pathogenic pathway induced by interleukin-6.Brain, behavior, and immunity · 2019Article
- In utero exposure to diesel exhaust is associated with alterations in neonatal cardiomyocyte transcription, DNA methylation and metabolic perturbation.Particle and fibre toxicology · 2019Article
- In utero exposure to ultrafine particles promotes placental stress-induced programming of renin-angiotensin system-related elements in the offspring results in altered blood pressure in adult mice.Particle and fibre toxicology · 2019Article
- Should Perturbation of the Preconceptive Environment be Considered a Risk Factor for the Development of Cardiovascular Disease Later in Life?Journal of the American Heart Association · 2018Article
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8 authors.
Funding
Abstract
backgroundFine particulate air pollution (PM2.5) is a global health concern, as exposure to PM2.5 has consistently been found to be associated with increased cardiovascular morbidity and mortality. Although adult exposure to traffic related PM2.5, which is largely derived from diesel exhaust (DE), has been associated with increased cardiac hypertrophy, there are limited investigations into the potential effect of in utero and early life exposure on adult susceptibility to heart disease. In this study, we investigate the effect of in utero and early life exposure to DE on adult susceptibility to heart failure.
methodsFemale C57BL/6 J mice were exposed to either filtered air (FA) or DE for 3 weeks (≈ 300 μg/m3 PM2.5 for 6 hours/day, 5 days/week) and then introduced to male breeders for timed matings. Female mice were exposed to either FA or DE throughout pregnancy and until offspring were 3 weeks of age. Offspring were then transferred to either FA or DE for an additional 8 weeks of exposure. At 12 weeks of age, male offspring underwent a baseline echocardiographic assessment, followed by a sham or transverse aortic constriction (TAC) surgery to induce pressure overload. Following sacrifice three weeks post surgery, ventricles were processed for histology to assess myocardial fibrosis and individual cardiomyocyte hypertrophy. mRNA from lung tissue was isolated to measure expression of inflammatory cytokines IL6 and TNFα.
resultsWe observed that mice exposed to DE during in utero and early life development have significantly increased susceptibility to cardiac hypertrophy, systolic failure, myocardial fibrosis, and pulmonary congestion following TAC surgery compared to FA control, or adult DE exposed mice. In utero and early life DE exposure also strongly modified the inflammatory cytokine response in the adult lung.
conclusionsWe conclude that exposure to diesel exhaust air pollution during in utero and early life development in mice increases adult susceptibility to heart failure. The results of this study may imply that the effects of air pollution on cardiovascular disease in human populations may be strongly mediated through a 'fetal origins' of adult disease pathway. Further investigations on this potential pathway of disease are warranted.
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