ArticleVirology journal2013
Genetic mutations in influenza H3N2 viruses from a 2012 epidemic in Southern China.
Article in Virology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Evolving Dynamics of Whole-Genome Influenza A/H3N2 Viruses Isolated in Cameroon.Advances in virology · 2025Article
- Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023.Nature communications · 2024Article
- Article
- Evolution of Swine Influenza Virus H3N2 in Vaccinated and Nonvaccinated Pigs after Previous Natural H1N1 Infection.Viruses · 2022Article
- Phylogenetic analysis of the hemagglutinin gene of influenza A(H1N1)pdm09 and A(H3N2) virus isolates from Haryana, India.Virusdisease · 2019Article
- Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2015-2016.Antiviral research · 2017Article
- Charged amino acid variability related to N-glyco -sylation and epitopes in A/H3N2 influenza: Hem -agglutinin and neuraminidase.PloS one · 2017Article
- Bioinformatics studies of Influenza A hemagglutinin sequence data indicate recombination-like events leading to segment exchanges.BMC research notes · 2016Article
- A humoral immunity survey following the 2012 influenza season after the pH1N1 pandemic in Guangzhou, China.Viral immunology · 2014Article
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Authors and funding
10 authors.
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Abstract
backgroundAn influenza H3N2 epidemic occurred throughout Southern China in 2012.
methodsWe analyzed the hemagglutinin (HA) and neuraminidase (NA) genes of influenza H3N2 strains isolated between 2011-2012 from Guangdong. Mutation sites, evolutionary selection, antigenic sites, and N-glycosylation within these strains were analyzed.
resultsThe 2011-2012 Guangdong strains contained the HA-A214S, HA-V239I, HA-N328S, NA-L81P, and NA-D93G mutations, similar to those seen in the A/ Perth/16/2009 influenza strain. The HA-NSS061-063 and NNS160-162 glycosylation sites were prevalent among the 2011-2012 Guangdong strains but the NA-NRS402-404 site was deleted. Antigenically, there was a four-fold difference between A/Perth/16/2009 -like strains and the 2011-2012 Guangdong strains.
conclusionAntigenic drift of the H3N2 subtype contributed to the occurrence of the Southern China influenza epidemic of 2012.
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