Evidence map›Paper›PMID 24279500›Full record

ReviewTraffic (Copenhagen, Denmark)2014

Enriching the pore: splendid complexity from humble origins.

Mark C Field, Ludek Koreny, Michael P Rout

Abstract readReview
In one paragraph

Review in Traffic (Copenhagen, Denmark), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Evolutionary trajectory for nuclear functions of ciliary transport complex proteins.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. The nucleus: keeping it together by keeping it apart.Current opinion in cell biology · 2017
    Review
  14. Article
  15. Torsin ATPases: Harnessing Dynamic Instability for Function.Frontiers in molecular biosciences · 2017
    Article
  16. O-fucosylated glycoproteins form assemblies in close proximity to the nuclear pore complexes of Toxoplasma gondii.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Mark C FieldDivision of Biological Chemistry and Drug Discovery, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland.
Ludek Koreny
Michael P Rout
University of Dundee · GBRockefeller University · US

Funding

New Tools for Exploring the Dynamic Interactome (Renewal)U54GM103511 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2012 to 2013
$6.2M
Nucleocytoplasmic transport: a target for cellular controlU01GM098256 · NIGMS · ROCKEFELLER UNIVERSITY · PI AITCHISON, JOHN D., ROUT, MICHAEL P · 2011 to 2014
$3.0M
The development of tools for proteomic analysis in trypanosomesR21AI096069 · NIAID · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2011 to 2012
$466k
Medical Research Council MR/K008749/1NIAID NIH HHS R21 AI096069NIGMS NIH HHS U01 GM098256NIGMS NIH HHS U54 GM103511Wellcome TrustWellcome Trust 090007/Z/09/Z
6 · The paper itself

Abstract

The nucleus is the defining intracellular organelle of eukaryotic cells and represents a major structural innovation that differentiates the eukaryotic and prokaryotic cellular form. The presence of a nuclear envelope (NE) encapsulating the nucleus necessitates a mechanism for interchange between the contents of the nuclear interior and the cytoplasm, which is mediated via the nuclear pore complex (NPC), a large protein assembly residing in nuclear pores in the NE. Recent advances have begun to map the structure and functions of the NPC in multiple organisms, and to allow reconstruction of some of the evolutionary events that underpin the modern NPC form, highlighting common and differential NPC features across the eukaryotes. Here we discuss some of these advances and the questions being pursued, consider how the evolution of the NPC has been constrained, and finally propose a model for how the NPC evolved.

Indexed as

Evolution, MolecularActive Transport, Cell NucleusAnimalsHumansNuclear PoreNuclear Pore Complex ProteinsNuclear Pore Complex Proteinscomparative genomicseukaryogenesismolecular evolutionnuclear pore complexnucleusprotocoatomer

Identifiers

PMID24279500
PMCPMC3906644
OpenAlexW1572498622

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.