ArticleJournal of translational medicine2013
Circulating microRNA: a novel potential biomarker for early diagnosis of intracranial aneurysm rupture a case control study.
Article in Journal of translational medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- The diagnostic value of miR-338-3p in acute coronary syndrome and its correlation with MACE occurrence.Journal of cardiothoracic surgery · 2026Article
- The Role of miRNA Expression Profiles in Different Biofluids in Aneurysm Rupture.Journal of Korean Neurosurgical Society · 2025Article
- The Role of Non-Coding RNAs in ALS.Genes · 2025Review
- Intracranial Aneurysm Biomarkers: A Convergence of Genetics, Inflammation, Oxidative Stress, and the Extracellular Matrix.International journal of molecular sciences · 2025Review
- The Potential Contribution of MyomiRs miR-133a-3p, -133b, and -206 Dysregulation in Cardiovascular Disease Risk.International journal of molecular sciences · 2024Article
- The Role of Epigenetics in Brain Aneurysm and Subarachnoid Hemorrhage: A Comprehensive Review.International journal of molecular sciences · 2024Review
- The role of MicroRNA as a potential diagnostic and prognostic biomarker for cerebral aneurysms.Neurosciences (Riyadh, Saudi Arabia) · 2023Article
- Review
- Identification of Serum miR-501-3p and miR-338-3p as Novel Diagnostic Biomarkers for Breast Cancer and Their Target Genes Associated with Immune Infiltration.International journal of general medicine · 2023Article
- Altered MicroRNA Expression in Intracranial Aneurysmal Tissues: Possible Role in TGF-β Signaling Pathway.Cellular and molecular neurobiology · 2022Article
- Extracellular Vesicles and Their Associated miRNAs as Potential Biomarkers in Intracranial Aneurysm.Frontiers in molecular biosciences · 2022Review
- MicroRNAs as Biomarkers for Predicting Complications following Aneurysmal Subarachnoid Hemorrhage.International journal of molecular sciences · 2021Review
- A Two-Gene-Based Diagnostic Signature for Ruptured Intracranial Aneurysms.Frontiers in cardiovascular medicine · 2021Article
- Characterization of Long Non-coding RNA Signatures of Intracranial Aneurysm in Circulating Whole Blood.Molecular diagnosis & therapy · 2020Article
- Classification models using circulating neutrophil transcripts can detect unruptured intracranial aneurysm.Journal of translational medicine · 2020Article
- MicroRNAs in ascending thoracic aortic aneurysms.Bioscience reports · 2020Observational
- Exosome-Derived MiRNAs as Biomarkers of the Development and Progression of Intracranial Aneurysms.Journal of atherosclerosis and thrombosis · 2020Article
- Circulating MicroRNAs as Potential Molecular Biomarkers for Intracranial Aneurysmal Rupture.Molecular diagnosis & therapy · 2020Article
- Opposite regulation of piRNAs, rRNAs and miRNAs in the blood after subarachnoid hemorrhage.Journal of molecular medicine (Berlin, Germany) · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate warning effect of serum miRNA for intracranial aneurysm rupture through microarray hybridization.
methods24 were selected from 560 patients in our department and divided into group A, B, C and D. They are aneurysms with daughter aneurysms group, aneurysm without daughter aneurysms group, ruptured aneurysms group and angiography negative group. Then a microarray study was carried out using serum miRNA. Differentially expressed miRNAs were identified. Cluster analysis was performed in order to make the results looks more intuitive and potential gene targets were retrieved from miRNA target prediction databases.
resultsMicroarray study identified 86 miRNAs with significantly different (p < 0.05) expression levels between three experimental groups and control group. Among them 69 are up-regulated and 17 are down-regulated. All miRNAs in group A are up-regulated, while there are up and down-regulated in group B and C. A total of 8291 predicted target genes are related to these miRNAs. Bioinformatic analysis revealed that several target genes are involved in apoptosis and activation of cells associated with function of vascular wall.
conclusionOur gene level approach reveals several different serum miRNAs between normal people and aneurysm patients, as well as among different phases of aneurysm, suggesting that miRNA may participate in the regulation of the occurrence and development of intracranial aneurysm, and also have warning effect for intracranial aneurysm rupture. All differently expressed miRNA in group A are up-regulated, which may suggesting protective function of miRNA for intracranial vascular wall.
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