Evidence map›Paper›PMID 24278954›Full record

ReviewThe International journal of oral & maxillofacial implants

Temporomandibular disorders: a review of etiology, clinical management, and tissue engineering strategies.

Meghan K Murphy, Regina F MacBarb, Mark E Wong, Kyriacos A Athanasiou

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The International journal of oral & maxillofacial implants. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07670832 (Effect of Temporomandibular Joint Compression and Decompression Technique on Maximum Mouth Opening Width, Masseter Muscle Tone and Stiffness), which is not on this map. Cited by 168 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 5 pooled it
23.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07670832 nanot yet recruitingnot on this map

Effect of Temporomandibular Joint Compression and Decompression Technique on Maximum Mouth Opening Width, Masseter Muscle Tone and Stiffness: A Randomized Controlled Study

TypeinterventionalSponsorEscola Superior de Tecnologia da Saúde do PortoRan2026 to 2026Enrolled32ConditionsAsymptomatic ConditionArmsOsteopathic Intervention Techniques, Placebo Technique
3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 5 syntheses or guidelines pooled it, 400 citations in OpenAlex.

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108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Meghan K Murphy
Regina F MacBarb
Mark E Wong
Kyriacos A Athanasiou
University of California, Davis · USNational Medical Research Center of Dentistry and Maxillofacial Surgery · RU

Funding

TMJ Disc RegenerationR01DE015038 · NIDCR · UNIVERSITY OF CALIFORNIA-IRVINE · PI ATHANASIOU, KYRIACOS A · 2004 to 2022
$6.1M
Regenerating the fibrocartilage spectrum of the TMJ: from disc to condyleR01DE019666 · NIDCR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ATHANASIOU, KYRIACOS A · 2010 to 2013
$1.4M
NIDCR NIH HHS R01 DE015038NIDCR NIH HHS R01 DE019666NIDCR NIH HHS R01DE019666
6 · The paper itself

Abstract

Temporomandibular disorders (TMD) are a class of degenerative musculoskeletal conditions associated with morphologic and functional deformities that affect up to 25% of the population, but their etiology and progression are poorly understood and, as a result, treatment options are limited. In up to 70% of cases, TMD are accompanied by malpositioning of the temporomandibular joint (TMJ) disc, termed "internal derangement." Although the onset is not well characterized, correlations between internal derangement and osteoarthritic change have been identified. Because of the complex and unique nature of each TMD case, diagnosis requires patient-specific analysis accompanied by various diagnostic modalities. Likewise, treatment requires customized plans to address the specific characteristics of each patient's disease. In the mechanically demanding and biochemically active environment of the TMJ, therapeutic approaches that can restore joint functionality while responding to changes in the joint have become a necessity. One such approach, tissue engineering, which may be capable of integration and adaptation in the TMJ, carries significant potential for the development of repair and replacement tissues. The following review presents a synopsis of etiology, current treatment methods, and the future of tissue engineering for repairing and/or replacing diseased joint components, specifically the mandibular condyle and TMJ disc. An analysis of native tissue characterization to assist clinicians in identifying tissue engineering objectives and validation metrics for restoring healthy and functional structures of the TMJ is followed by a discussion of current trends in tissue engineering.

Indexed as

Temporomandibular Joint DiscTemporomandibular Joint DisordersCartilage, ArticularDisease ProgressionHumansMaleMandibular CondyleTemporomandibular JointTissue Engineering

Identifiers

PMID24278954
PMCPMC4349514
OpenAlexW2079524438

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.