ReviewScientifica2013
Nature and nurture of human pain.
Review in Scientifica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Pulsed electromagnetic fields for post-appendicectomy pain management: a randomized, placebo-controlled trial.Trials · 2022Trial
- Digital Approaches to Pain Assessment Across Older Adults: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Imaging findings of irritable bowel syndrome patients, and the diagnostic value of irritable bowel syndrome: A systematic review.World journal of methodology · 2025Article
- Classifying social and physical pain from multimodal physiological signals using machine learning.Scientific reports · 2025Article
- Long-term back pain recall in Generation XXI adolescents: the role of sensitivity and pain history.Pain reports · 2025Article
- Qualitative analysis of pain in cancer patients - psychological and clinical aspects.Archives of medical science : AMS · 2025Article
- Effect of intravenous magnesium on post-operative pain following Latarjet shoulder reconstruction.Shoulder & elbow · 2024Article
- Association Between Eye Color and Postoperative Pain in Female Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars: A Prospective, Parallel-Group, Observational Study.Pain research & management · 2024Observational
- Integrating the Gut Microbiome and Stress-Diathesis to Explore Post-Trauma Recovery: An Updated Model.Pathogens (Basel, Switzerland) · 2022Article
- Identifying who best tolerates moderate sedation: Results from a national database of gastrointestinal endoscopic outcomes.World journal of gastrointestinal endoscopy · 2021Article
- Observational
- Chronic postsurgical pain: is there a possible genetic link?British journal of pain · 2017Article
- Article
- Sex-Specific Genetic Control of Diabetic Neuropathic Pain Suggests Subsequent Development of Men-only and Women-Only Analgesic Strategies.EBioMedicine · 2015Article
- Vitamin D and Pain: Vitamin D and Its Role in the Aetiology and Maintenance of Chronic Pain States and Associated Comorbidities.Pain research and treatment · 2015Review
- The design and methods of genetic studies on acute and chronic postoperative pain in patients after total knee replacement.Pain medicine (Malden, Mass.) · 2014Observational
- An interprofessional consensus of core competencies for prelicensure education in pain management: curriculum application for physical therapy.Physical therapy · 2014Article
- Guest Editorial.British journal of pain · 2013Article
- Erythromelalgia: a cutaneous manifestation of neuropathy?Anais brasileiros de dermatologiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Humans are very different when it comes to pain. Some get painful piercings and tattoos; others can not stand even a flu shot. Interindividual variability is one of the main characteristics of human pain on every level including the processing of nociceptive impulses at the periphery, modification of pain signal in the central nervous system, perception of pain, and response to analgesic strategies. As for many other complex behaviors, the sources of this variability come from both nurture (environment) and nature (genes). Here, I will discuss how these factors contribute to human pain separately and via interplay and how epigenetic mechanisms add to the complexity of their effects.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.