ReviewScientifica2012
The role of proteins in biosilicification.
Review in Scientifica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Data-driven inverse design of multifunctional bicontinuous multiscale structures.Nature communications · 2026Article
- Multi-domain temporal patterns reveal stable community membership but dynamic interactions in the coastal microbiome.Environmental microbiome · 2025Article
- Article
- Harnessing Microalgae as Sustainable Cell Factories for Polyamine-Based Nanosilica for Biomedical Applications.Molecules (Basel, Switzerland) · 2025Review
- An Atomistic View on the Mechanism of Diatom Peptide-Guided Biomimetic Silica Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Biominerals and Bioinspired Materials in Biosensing: Recent Advancements and Applications.International journal of molecular sciences · 2024Review
- Silica-associated proteins from hexactinellid sponges support an alternative evolutionary scenario for biomineralization in Porifera.Nature communications · 2024Article
- A novel effective bio-originated methylene blue adsorbent: the porous biosilica from three marine diatom strains of Nanofrustulum spp. (Bacillariophyta).Scientific reports · 2023Article
- Article
- Elevated pH Conditions Associated WithFrontiers in microbiology · 2021Article
- In-silico Exploration of Channel Type and Efflux Silicon Transporters and Silicification Proteins in 80 Sequenced Viridiplantae Genomes.Plants (Basel, Switzerland) · 2020Article
- On the Potential of Silicon as a Building Block for Life.Life (Basel, Switzerland) · 2020Article
- Quantitative Proteomic Profiling of Marine DiatomFrontiers in microbiology · 2020Article
- Phytolith Formation in Plants: From Soil to Cell.Plants (Basel, Switzerland) · 2019Review
- Metatranscriptomic Signatures Associated With Phytoplankton Regime Shift From Diatom Dominance to a Dinoflagellate Bloom.Frontiers in microbiology · 2019Article
- Efficient silica synthesis from tetra(glycerol)orthosilicate with cathepsin- and silicatein-like proteins.Scientific reports · 2018Article
- Coding cell micropatterns through peptide inkjet printing for arbitrary biomineralized architectures.Advanced functional materials · 2018Article
- Silica formation with nanofiber morphology via helical display of the silaffin R5 peptide on a filamentous bacteriophage.Scientific reports · 2017Article
- Multiscale design and synthesis of biomimetic gradient protein/biosilica composites for interfacial tissue engineering.Biomaterials · 2017Article
- The C-Terminal Zwitterionic Sequence of CotB1 Is Essential for Biosilicification of the Bacillus cereus Spore Coat.Journal of bacteriology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the use of silicon dioxide (silica) as a constituent of living organisms is mainly restricted to diatoms and sponges, the ways in which this process is controlled by nature continue to inspire and fascinate. Both diatoms and sponges carry out biosilificiation using an organic matrix but they adopt very different strategies. Diatoms use small and heavily modified peptides called silaffins, where the most characteristic feature is a modulation of charge by attaching long chain polyamines (LCPAs) to lysine groups. Free LCPAs can also cooperate with silaffins. Sponges use the enzyme silicatein which is homologous to the cysteine protease cathepsin. Both classes of proteins form higher-order structures which act both as structural templates and mechanistic catalysts for the polycondensation reaction. In both cases, additional proteins are continuously being discovered which modulate the process further. This paper concentrates on the role of these proteins in the biosilification process as well as in various applications, highlighting areas where focus on specific protein properties may provide further insight. The field of biosilification is a crossroads of different disciplines, where insight into the energetics and mechanisms of molecular self-assembly combine with fundamental biology, complex multicomponent colloidal systems, and an impressive array of potential technological applications.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.