ArticlePLoS neglected tropical diseases2013
Recent emergence and spread of an Arctic-related phylogenetic lineage of rabies virus in Nepal.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epidemiology, Impact and Control of Rabies in Nepal: A Systematic Review.PLoS neglected tropical diseases · 2016Pooled it
- Comprehensive genomic analysis of rabies virus in India reveals distinct lineages and evolutionary stability.Virus genes · 2026Article
- Arctic-like lineage of rabies virus detected in Indian wild fox: a case study.Veterinary research forum : an international quarterly journal · 2026Article
- Rabies Elimination: Is It Feasible without Considering Wildlife?Journal of tropical medicine · 2022Review
- On the Use of Phylogeographic Inference to Infer the Dispersal History of Rabies Virus: A Review Study.Viruses · 2021Review
- Molecular evolutionary analysis reveals Arctic-like rabies viruses evolved and dispersed independently in North and South Asia.Journal of veterinary science · 2021Article
- Portable Rabies Virus Sequencing in Canine Rabies Endemic Countries Using the Oxford Nanopore MinION.Viruses · 2020Article
- Article
- Molecular epidemiological analysis of wild animal rabies isolates from India.Veterinary world · 2019Article
- The reemergence of human rabies and emergence of an Indian subcontinent lineage in Tibet, China.PLoS neglected tropical diseases · 2019Article
- Sequencing and sequence analysis of partial nucleoprotein (N) gene and phylogenetic analysis of rabies virus field isolates from Gujarat state, India.Virusdisease · 2017Article
- Large-Scale Phylogenomic Analysis Reveals the Complex Evolutionary History of Rabies Virus in Multiple Carnivore Hosts.PLoS pathogens · 2016Article
- Complete Genome Sequence of a Rabies Virus Strain Isolated from a Brown Bear (Ursus arctos) in Primorsky Krai, Russia (November 2014).Genome announcements · 2016Article
- Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland.PLoS neglected tropical diseases · 2016Article
- Dual Combined Real-Time Reverse Transcription Polymerase Chain Reaction Assay for the Diagnosis of Lyssavirus Infection.PLoS neglected tropical diseases · 2016Article
- Molecular and immunogenic characterization of BHK-21 cell line adapted CVS-11 strain of rabies virus and future prospect in vaccination strategy.Virusdisease · 2015Article
- Complex epidemiology of a zoonotic disease in a culturally diverse region: phylogeography of rabies virus in the Middle East.PLoS neglected tropical diseases · 2015Article
- Natural Rabies Infection in a Domestic Fowl (Gallus domesticus): A Report from India.PLoS neglected tropical diseases · 2015Article
- Molecular characterization of nucleoprotein gene of rabies virus from Maharashtra, India.Journal of postgraduate medicineArticle
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9 authors.
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Abstract
Rabies is a zoonotic disease that is endemic in many parts of the developing world, especially in Africa and Asia. However its epidemiology remains largely unappreciated in much of these regions, such as in Nepal, where limited information is available about the spatiotemporal dynamics of the main etiological agent, the rabies virus (RABV). In this study, we describe for the first time the phylogenetic diversity and evolution of RABV circulating in Nepal, as well as their geographical relationships within the broader region. A total of 24 new isolates obtained from Nepal and collected from 2003 to 2011 were full-length sequenced for both the nucleoprotein and the glycoprotein genes, and analysed using neighbour-joining and maximum-likelihood phylogenetic methods with representative viruses from all over the world, including new related RABV strains from neighbouring or more distant countries (Afghanistan, Greenland, Iran, Russia and USA). Despite Nepal's limited land surface and its particular geographical position within the Indian subcontinent, our study revealed the presence of a surprising wide genetic diversity of RABV, with the co-existence of three different phylogenetic groups: an Indian subcontinent clade and two different Arctic-like sub-clades within the Arctic-related clade. This observation suggests at least two independent episodes of rabies introduction from neighbouring countries. In addition, specific phylogenetic and temporal evolution analysis of viruses within the Arctic-related clade has identified a new recently emerged RABV lineage we named as the Arctic-like 3 (AL-3) sub-clade that is already widely spread in Nepal.
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