ArticlePloS one2013
A novel in vitro model to study pericytes in the neurovascular unit of the developing cortex.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Endothelial Cell-Pericyte Crosstalk in the Brain Balances Microvascular Stability and Plasticity.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- An ex vivo injury model perfused with whole blood reveals rapid mechanical and transcriptional changes within the spinal cord.Bioengineering & translational medicine · 2026Article
- Chemogenetic modulation of CNS pericytes: Impact on pericyte CaMolecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders.Frontiers in cellular neuroscience · 2023Review
- Neuroprotective mechanisms of DNA methyltransferase in a mouse hippocampal neuronal cell line after hypoxic preconditioning.Neural regeneration research · 2020Article
- Atherosclerosis and the Capillary Network; Pathophysiology and Potential Therapeutic Strategies.Cells · 2019Review
- Article
- Targeting pericytes for neurovascular regeneration.Cell communication and signaling : CCS · 2019Review
- Targeting pericytes for therapeutic approaches to neurological disorders.Acta neuropathologica · 2018Review
- The physiological functions of central nervous system pericytes and a potential role in pain.F1000Research · 2018Review
- Mild systemic inflammation and moderate hypoxia transiently alter neuronal excitability in mouse somatosensory cortex.Neurobiology of disease · 2016Article
- Organotypic brain slice cultures: A review.Neuroscience · 2015Review
- Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex.Scientific reports · 2015Article
- Organotypic brain slice cultures as a model to study angiogenesis of brain vessels.Frontiers in cell and developmental biology · 2015Article
- The role of pericytes in neurovascular unit remodeling in brain disorders.International journal of molecular sciences · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortical function is impaired in various disorders of the central nervous system including Alzheimer's disease, autism and schizophrenia. Some of these disorders are speculated to be associated with insults in early brain development. Pericytes have been shown to regulate neurovascular integrity in development, health and disease. Hence, precisely controlled mechanisms must have evolved in evolution to operate pericyte proliferation, repair and cell fate within the neurovascular unit (NVU). It is well established that pericyte deficiency leads to NVU injury resulting in cognitive decline and neuroinflammation in cortical layers. However, little is known about the role of pericytes in pathophysiological processes of the developing cortex. Here we introduce an in vitro model that enables to precisely study pericytes in the immature cortex and show that moderate inflammation and hypoxia result in caspase-3 mediated pericyte loss. Using heterozygous EYFP-NG2 mouse mutants we performed live imaging of pericytes for several days in vitro. In addition we show that pericytes maintain their capacity to proliferate which may allow cell-based therapies like reprogramming of pericytes into induced neuronal cells in the presented approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.