ArticlePloS one2013
Modified uterine allotransplantation and immunosuppression procedure in the sheep model.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Pharmacokinetics of immunosuppressive agents during hemoperfusion in a sheep model.Frontiers in medicine · 2023Article
- Experimental Static Cold Storage of the Rat Uterus: Protective Effects of Relaxin- or Erythropoietin-Supplemented HTK-N Solutions.Biomedicines · 2022Article
- Involving Animal Models in Uterine Transplantation.Frontiers in surgery · 2022Review
- Uterus transplantation in a sheep model: novel surgical technique with long-term survival and uterus vitality. First case series in Argentina.JBRA assisted reproduction · 2021Article
- Custodiol-N Is Superior to CustodiolInternational journal of molecular sciences · 2020Article
- The Fetal-Maternal Immune Interface in Uterus Transplantation.Trends in immunology · 2020Review
- Successful orthotopic uterine allotransplantation in a rabbit model using aorta and cava anastomoses: a short-term viability study.Archives of gynecology and obstetrics · 2020Article
- Review
- Changes in the metabolic composition of storage solution with prolonged cold ischemia of the uterus.Journal of assisted reproduction and genetics · 2019Article
- Laparoscopic uterine graft procurement and surgical autotransplantation in ovine model.Scientific reports · 2019Article
- The Key Role of Warm and Cold Ischemia in Uterus Transplantation: A Review.Journal of clinical medicine · 2019Review
- Current Progress in Uterus Transplantation Research in Asia.Journal of clinical medicine · 2019Review
- A large animal model for standardized testing of bone regeneration strategies.BMC veterinary research · 2018Article
- Uterus transplantation: Toward clinical application in Japan.Reproductive medicine and biology · 2017Review
- The history behind successful uterine transplantation in humans.JBRA assisted reproduction · 2017Review
- Uterus transplantation and beyond.Journal of materials science. Materials in medicine · 2017Review
- Sheep Model for Uterine Transplantation: The Best Option Before Starting a Human Program.Clinics (Sao Paulo, Brazil) · 2017Article
- Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches.Cellular & molecular immunology · 2017Review
- Uterus transplantation: A clinical breakthrough after systematic preclinical research.Reproductive medicine and biologyReview
- Experimental brain infection with cysticercosis in sheep.Revista peruana de medicina experimental y salud publicaArticle
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo develop an orthotopic, allogeneic, uterine transplantation technique and an effective immunosuppressive protocol in the sheep model.
methodsIn this pilot study, 10 sexually mature ewes were subjected to laparotomy and total abdominal hysterectomy with oophorectomy to procure uterus allografts. The cold ischemic time was 60 min. End-to-end vascular anastomosis was performed using continuous, non-interlocking sutures. Complete tissue reperfusion was achieved in all animals within 30 s after the vascular re-anastomosis, without any evidence of arterial or venous thrombosis. The immunosuppressive protocol consisted of tacrolimus, mycophenolate mofetil and methylprednisolone tablets. Graft viability was assessed by transrectal ultrasonography and second-look laparotomy at 2 and 4 weeks, respectively.
resultsViable uterine tissue and vascular patency were observed on transrectal ultrasonography and second-look laparotomy. Histological analysis of the graft tissue (performed in one ewe) revealed normal tissue architecture with a very subtle inflammatory reaction but no edema or stasis.
conclusionWe have developed a modified procedure that allowed us to successfully perform orthotopic, allogeneic, uterine transplantation in sheep, whose uterine and vascular anatomy (apart from the bicornuate uterus) is similar to the human anatomy, making the ovine model excellent for human uterine transplant research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.