ArticlePloS one2013
Risk factors for fatality among confirmed adult dengue inpatients in Singapore: a matched case-control study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Diabetes mellitus as a risk factor for severe dengue fever and West Nile fever: A meta-analysis.PLoS neglected tropical diseases · 2024Pooled it
- Prevalence of chronic comorbidities in dengue fever and West Nile virus: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Relevance of Non-communicable Comorbidities for the Development of the Severe Forms of Dengue: A Systematic Literature Review.PLoS neglected tropical diseases · 2016Pooled it
- Predictive symptoms and signs of severe dengue disease for patients with dengue fever: a meta-analysis.BioMed research international · 2014Pooled it
- Infection-associated acute kidney injury in resource-limited settings.Nature reviews. Nephrology · 2026Review
- Assessing the burden of diabetes mellitus in dengue patients: A systematic review and meta-analysis.New microbes and new infections · 2026Article
- Risk factors associated with dengue lethality: case-control study, Joinville, Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2026Article
- Predictors of Clinically Significant Bleeding in Thrombocytopenic Dengue Patients Admitted to Intensive Care Unit: A Retrospective Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023Article
- Development and Utility of Practical Indicators of Critical Outcomes in Dengue Patients Presenting to Hospital: A Retrospective Cross-Sectional Study.Tropical medicine and infectious disease · 2023Article
- Predictors of Mortality in Patients With Dengue Fever: Insights From a Comparative Analysis.Cureus · 2023Article
- Cell Strain-Derived Induced Pluripotent Stem Cells as an Isogenic Approach To Investigate Age-Related Host Response to Flaviviral Infection.Journal of virology · 2022Article
- Dengue and Chikungunya virus co-infection in major metropolitan cities of provinces of Punjab and Khyber Pakhtunkhwa: A multi-center study.PLoS neglected tropical diseases · 2021Article
- Dengue: A Minireview.Viruses · 2020Review
- Risk Factors and Predictors of Severe Dengue in Saudi Population in Jeddah, Western Saudi Arabia: A Retrospective Study.The American journal of tropical medicine and hygiene · 2020Article
- Severity Index for Suspected Arbovirus (SISA): Machine learning for accurate prediction of hospitalization in subjects suspected of arboviral infection.PLoS neglected tropical diseases · 2020Article
- Notified dengue deaths in Myanmar (2017-18): profile and diagnosis delays.F1000Research · 2020Article
- Impaired production of immune mediators in dengue virus type 2-infected mononuclear cells of adults with end stage renal disease.Scientific reports · 2019Article
- Trajectories of hepatic and coagulation dysfunctions related to a rapidly fatal outcome among hospitalized patients with dengue fever in Tainan, 2015.PLoS neglected tropical diseases · 2019Article
- Risk Factors Associated with Dengue Virus Infection in Guangdong Province: A Community-Based Case-Control Study.International journal of environmental research and public health · 2019Article
- Clinical Indicators of Fatal Dengue in Two Endemic Areas of Colombia: A Hospital-Based Case-Control Study.The American journal of tropical medicine and hygiene · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo identify demographic, clinical and laboratory risk factors for death due to dengue fever in adult patients in Singapore.
methodsMulti-center retrospective study of hospitalized adult patients with confirmed dengue fever in Singapore between 1 January 2004 and 31 December 2008. Non-fatal controls were selected by matching age and year of infection with fatal cases. World Health Organization 1997, 2009 criteria were applied to define dengue hemorrhagic fever (DHF), warning signs and severe dengue. Statistical significance was assessed by conditional logistic regression modeling.
resultsSignificantly more fatal cases than matched controls had pre-existing co-morbid conditions, and presented with abdominal pain/tenderness. Median pulse rates were significantly higher while myalgia was significantly less frequent in cases. . Fatal cases also had higher leucocyte counts, platelet counts, serum sodium, potassium, urea, creatine and bilirubin levels on admission compared to controls. There was no statistical significant difference between the prevalence of DHF and hematocrit level among cases and controls. Multivariate analysis showed myalgia and leucocyte count at presentation were independent predictors of fatality (adjusted odds ratios 0.09 and 2.94 respectively). None of the controls was admitted to intensive care unit (ICU) or given blood transfusion, while 71.4% and 28.6% of fatal cases received ICU admission and blood transfusion.
conclusionsAbsence of myalgia and leucocytosis on admission were independently associated with fatality in our matched case-control study. Fatalities were also commonly associated with co-morbidities and clinicians should be alarmed if dengue patients fulfilled severe dengue case definition on admission.
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