ArticlePloS one2013
Causes and outcomes of acute liver failure in China.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers, 3 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Liver support systems for adults with acute liver failure.The Cochrane database of systematic reviews · 2026Pooled it
- Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantation.Hepatology international · 2024Guideline
- Drug induced liver injury: East versus West - a systematic review and meta-analysis.Clinical and molecular hepatology · 2020Pooled it
- Effects of imbalanced gut microbial on mice with type a hepatic encephalopathy through the gut-liver-brain axis.Metabolic brain disease · 2026Article
- Animal models accurately representing acute liver failure (Review).International journal of molecular medicine · 2026Review
- Acute versus acute-on-chronic liver failure: comparative analysis of clinical outcomes in Beijing, China.BMC gastroenterology · 2025Article
- Single-cell transcriptome atlas reveals mitophagy dynamics in acute chemical injury model and the role of MSCs transplantation.Stem cell research & therapy · 2025Article
- Clinical characteristics and prognosis of non-APAP drug-induced acute liver failure: a large multicenter cohort study.Hepatology international · 2024Article
- Current progress on the microbial therapies for acute liver failure.Frontiers in microbiology · 2024Review
- COVID-19 vaccination-related hemophagocytic lymphohistiocytosis presenting as acute liver failure.Proceedings (Baylor University. Medical Center) · 2023Article
- Pluripotent Stem Cell-derived Strategies to Treat Acute Liver Failure: Current Status and Future Directions.Journal of clinical and translational hepatology · 2022Review
- Identifying the Mechanism of Polygoni Cuspidati Rhizoma et Radix in Treating Acute Liver Failure Based on Network Pharmacology and Molecular Docking.Gastroenterology research and practice · 2022Article
- Herbal medicines in functional dyspepsia-Untapped opportunities not without risks.Neurogastroenterology and motility · 2021Review
- Characteristics of Drug-Induced Liver Injury in Northeast China: Disease Spectrum and Drug Types.Digestive diseases and sciences · 2020Article
- [Neutralization of interleukin-6 alleviates acute liver injury in mice].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2020Article
- Epidemiological differences of common liver conditions between Asia and the West.JGH open : an open access journal of gastroenterology and hepatology · 2020Review
- The Epidemiology of Acute Liver Failure.Deutsches Arzteblatt international · 2020Article
- Knowledge Mapping of Drug-Induced Liver Injury: A Scientometric Investigation (2010-2019).Frontiers in pharmacology · 2020Article
- Severe liver injury due to herbal and dietary supplements and the role of liver transplantation.World journal of gastroenterology · 2019Review
- Complementary and Alternative Medicine-related Drug-induced Liver Injury in Asia.Journal of clinical and translational hepatology · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNo extensive investigation has been performed and thus no representative data are available regarding acute liver failure (ALF) in China. This study aims to investigate the causes and outcomes of ALF in China and establish a prognostic model.
methodsPatients diagnosed as ALF in seven hospitals in different areas of China from January 2007 to December 2012 were retrospectively selected.
resultsOf the 177 patients included in this study, 112 (63.28%) eventually died. The common causes of ALF were drug toxicity (43.50%), indeterminate etiology (29.38%) and acute viral hepatitis (11.30%). Additionally, traditional Chinese herbs predominated in the causes of drug-induced ALF (30/77). No patients in this study received liver transplantation. In the established model for predicting death in ALF, four variables were finally selected out, including age (P=0.01), the entry hepatic encephalopathy grade (P=0.04), international normalized ratio (P<0.01) and arterial blood ammonia (P=0.02). Using a threshold value of 0.5683, this model had a sensitivity of 95.24% and a specificity of 91.30%.
conclusionsTraditional Chinese medicine was a major cause of ALF in China. The spontaneous mortality of ALF was high, whereas the rate of liver transplantation was significantly low. The established prognostic model of ALF had superior sensitivity and specificity.
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