ArticlePloS one2013
Olfactory sensitivity for six predator odorants in CD-1 mice, human subjects, and spider monkeys.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Human pairs show collective benefit in olfactory perception despite individual differences and verbal limits.iScience · 2026Article
- Odour learning concentration influences concentration range of conditioned response in newborn rabbits.Scientific reports · 2025Article
- Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Behavioral and neurobiological implications of kairomones for rodents: an updated review.Frontiers in neuroscience · 2025Review
- Nature and human well-being: The olfactory pathway.Science advances · 2024Review
- What Does the Human Olfactory System Do, and How Does It Do It?Annual review of psychology · 2024Review
- The behavioral sensitivity of mice to acyclic, monocyclic, and bicyclic monoterpenes.PloS one · 2024Article
- Fear effects on bank voles (Rodentia: Arvicolinae): testing for repellent candidates from predator volatiles.Pest management science · 2022Article
- Evolution of brain-wide activity in the awake behaving mouse after acute fear by longitudinal manganese-enhanced MRI.NeuroImage · 2020Article
- Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate.Pharmaceutical research · 2020Article
- An Evolutionarily Threat-Relevant Odor Strengthens Human Fear Memory.Frontiers in neuroscience · 2020Article
- Could the Olfactory System Be a Target for Homeopathic Remedies as Nanomedicines?Journal of alternative and complementary medicine (New York, N.Y.) · 2018Article
- Olfactory sensitivity for mold-associated odorants in CD-1 mice and spider monkeys.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- Attractant or Repellent? Behavioral Responses to Mammalian Blood Odor and to a Blood Odor Component in a Mesopredator, the Meerkat (Frontiers in behavioral neuroscience · 2018Article
- fMRI study of the role of glutamate NMDA receptor in the olfactory processing in monkeys.PloS one · 2018Article
- Poor human olfaction is a 19th-century myth.Science (New York, N.Y.) · 2017Review
- The role of metals in mammalian olfaction of low molecular weight organosulfur compounds.Natural product reports · 2017Review
- Article
- Structure-Activity Relationships of Alkylpyrazine Analogs and Fear-Associated Behaviors in Mice.Journal of chemical ecology · 2017Article
- Chemical recognition of fruit ripeness in spider monkeys (Ateles geoffroyi).Scientific reports · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using a conditioning paradigm, we assessed the olfactory sensitivity of six CD-1 mice (Mus musculus) for six sulfur-containing odorants known to be components of the odors of natural predators of the mouse. With all six odorants, the mice discriminated concentrations <0.1 ppm (parts per million) from the solvent, and with five of the six odorants the best-scoring animals were even able to detect concentrations <1 ppt (parts per trillion). Four female spider monkeys (Ateles geoffroyi) and twelve human subjects (Homo sapiens) tested in parallel were found to detect the same six odorants at concentrations <0.01 ppm, and with four of the six odorants the best-scoring animals and subjects even detected concentrations <10 ppt. With all three species, the threshold values obtained here are generally lower than (or in the lower range of) those reported for other chemical classes tested previously, suggesting that sulfur-containing odorants may play a special role in olfaction. Across-species comparisons showed that the mice were significantly more sensitive than the human subjects and the spider monkeys with four of the six predator odorants. However, the human subjects were significantly more sensitive than the mice with the remaining two odorants. Human subjects and spider monkeys significantly differed in their sensitivity with only two of the six odorants. These comparisons lend further support to the notion that the number of functional olfactory receptor genes or the relative or absolute size of the olfactory bulbs are poor predictors of a species' olfactory sensitivity. Analysis of odor structure-activity relationships showed that in both mice and human subjects the type of alkyl rest attached to a thietane and the type of oxygen moiety attached to a thiol significantly affected olfactory sensitivity.
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