ArticlePloS one2013
Biocompatibility of a novel cyanoacrylate based tissue adhesive: cytotoxicity and biochemical property evaluation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Dual-mode analysis of ischemic stroke based on urine SERS spectra and carotid B-ultrasound.Science advances · 2026Article
- Formaldehyde Emissions From 2-Octyl Cyanoacrylate: Quantified Risk for Allergic Contact Dermatitis.Contact dermatitis · 2026Article
- Crosslinker-Free, Printable Alginate-Boronic Acid Hydrogel Adhesive with Enhanced Mechanical Performance for Soft Tissue Fixation.Molecules (Basel, Switzerland) · 2026Article
- Topical over Dermal Versus Transdermal Application of Cyanoacrylate in Wound Synthesis and Its Effects on Healing-Experimental Study.Bioengineering (Basel, Switzerland) · 2025Article
- PACA nanoparticles target and deliver sildenafil to rejuvenate aged mouse liver sinusoidal endothelial cells.Nanotheranostics · 2025Article
- Cyanoacrylate versus Collagen Membrane as a Sealing for Alveolar Ridge Preservation: A Randomized Clinical Trial.Journal of functional biomaterials · 2024Article
- Cyanoacrylate Adhesives for Cutaneous Wound Closure.Animals : an open access journal from MDPI · 2024Article
- Article
- Antimicrobial Activity and Cytotoxicity of Prepolymer Allyl 2-cyanoacrylate and 2-Octyl Cyanoacrylate Mixture Adhesives for Topical Wound Closure.Materials (Basel, Switzerland) · 2023Article
- Bio-macromolecular design roadmap towards tough bioadhesives.Chemical Society reviews · 2022Review
- Biodegradable and Biocompatible Adhesives for the Effective Stabilisation, Repair and Regeneration of Bone.Bioengineering (Basel, Switzerland) · 2022Review
- Investigation of surgical adhesives for vocal fold wound closure.The Laryngoscope · 2019Article
- The cytotoxic properties and apoptotic potential of N-butyl and 2-octyl cyanoacrylates used in surgical treatment of chronic venous insufficiency.Turk gogus kalp damar cerrahisi dergisi · 2019Article
- Cyanoacrylate glue in an inadvertent trabeculectomy flap tear.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- Cytotoxicity of Cyanoacrylate-Based Tissue Adhesives and Short-Term Preclinical In Vivo Biocompatibility in Abdominal Hernia Repair.PloS one · 2016Article
- Osmotically driven drug delivery through remote-controlled magnetic nanocomposite membranes.Biomicrofluidics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyanoacrylate (CA) is most widely used as a medical and commercial tissue adhesive because of easier wound closure, good cosmetic results and little discomfort. But, CA-based tissue adhesives have some limitations including the release of cytotoxic chemicals during biodegradation. In previous study, we made prepolymerized allyl 2-CA (PACA) based tissue adhesive, resulting in longer chain structure. In this study, we investigated a biocompatibility of PACA as alternative tissue adhesive for medical application, comparing with that of Dermabond® as commercial tissue adhesive. The biocompatibility of PACA was evaluated for short-term (24 hr) and long-term (3 and 7 days) using conventional cytotoxicity (WST, neutral red, LIVE/DEAD and TUNEL) assays, hematoxylin-eosin (H&E) and Masson trichrome (MT) staining. Besides we examined the biochemical changes in cells and DNA induced by PACA and Dermabond® utilizing Raman spectroscopy which could observe the denaturation and conformational changes in protein, as well as disintegration of the DNA/RNA by cell death. In particular, we analyzed Raman spectrum using the multivariate statistical methods including principal component analysis (PCA) and support vector machine (SVM). As a result, PACA and Dermabond® tissue adhesive treated cells and tissues showed no difference of the cell viability values, histological analysis and Raman spectral intensity. Also, the classification analysis by means of PCA-SVM classifier could not discriminate the difference between the PACA and Dermabond® treated cells and DNA. Therefore we suggest that novel PACA might be useful as potential tissue adhesive with effective biocompatibility.
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