ArticleThe Journal of physiology2014
Transition between fast and slow gamma modes in rat hippocampus area CA1 in vitro is modulated by slow CA3 gamma oscillations.
Article in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Synaptic communication within the microcircuits of pyramidal neurons and basket cells in the mouse prefrontal cortex.The Journal of physiology · 2025Article
- Oligomeric β-Amyloid Suppresses Hippocampal γ-Oscillations through Activation of the mTOR/S6K1 Pathway.Aging and disease · 2023Article
- Article
- Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit.PLoS computational biology · 2023Article
- μ-Opioid receptor activation modulates CA3-to-CA1 gamma oscillation phase-coupling.IBRO reports · 2019Article
- Particle-Mediated Gene Transfection and Organotypic Culture of Postmortem Human Retina.Translational vision science & technology · 2019Article
- Restoring wild-type-like CA1 network dynamics and behavior during adulthood in a mouse model of schizophrenia.Nature neuroscience · 2018Article
- In vitro characterization of gamma oscillations in the hippocampal formation of the domestic chick.The European journal of neuroscience · 2018Article
- Comparison of three gamma oscillations in the mouse entorhinal-hippocampal system.The European journal of neuroscience · 2018Article
- Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy.Scientific reports · 2018Article
- Hippocampal Theta-Gamma Coupling Reflects State-Dependent Information Processing in Decision Making.Cell reports · 2018Article
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Intrinsic Cornu Ammonis Area 1 Theta-Nested Gamma Oscillations Induced by Optogenetic Theta Frequency Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Local Optogenetic Induction of Fast (20-40 Hz) Pyramidal-Interneuron Network Oscillations in the In Vitro and In Vivo CA1 Hippocampus: Modulation by CRF and Enforcement of Perirhinal Theta Activity.Frontiers in cellular neuroscience · 2016Article
- Subregional differences in the generation of fast network oscillations in the rat medial prefrontal cortex (mPFC) in vitro.The Journal of physiology · 2015Article
- Fast gamma oscillations are generated intrinsically in CA1 without the involvement of fast-spiking basket cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Beyond the connectome: the dynome.Neuron · 2014Review
- Muscarinic cholinergic receptors modulate inhibitory synaptic rhythms in hippocampus and neocortex.Frontiers in synaptic neuroscience · 2014Review
- GettING in Touch With What Drives Your Inner Funky: Sources of CA1 Gamma Oscillations.Epilepsy currentsArticle
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hippocampal gamma oscillations have been associated with cognitive functions including navigation and memory encoding/retrieval. Gamma oscillations in area CA1 are thought to depend on the oscillatory drive from CA3 (slow gamma) or the entorhinal cortex (fast gamma). Here we show that the local CA1 network can generate its own fast gamma that can be suppressed by slow gamma-paced inputs from CA3. Moderate acetylcholine receptor activation induces fast (45 ± 1 Hz) gamma in rat CA1 minislices and slow (33 ± 1 Hz) gamma in CA3 minislices in vitro. Using pharmacological tools, current-source density analysis and intracellular recordings from pyramidal cells and fast-spiking stratum pyramidale interneurons, we demonstrate that fast gamma in CA1 is of the pyramidal-interneuron network gamma (PING) type, with the firing of principal cells paced by recurrent perisomal IPSCs. The oscillation frequency was only weakly dependent on IPSC amplitude, and decreased to that of CA3 slow gamma by reducing IPSC decay rate or reducing interneuron activation through tonic inhibition of interneurons. Fast gamma in CA1 was replaced by slow CA3-driven gamma in unlesioned slices, which could be mimicked in CA1 minislices by sub-threshold 35 Hz Schaffer collateral stimulation that activated fast-spiking interneurons but hyperpolarised pyramidal cells, suggesting that slow gamma frequency CA3 outputs can suppress the CA1 fast gamma-generating network by feed-forward inhibition and replaces it with a slower gamma oscillation driven by feed-forward inhibition. The transition between the two gamma oscillation modes in CA1 might allow it to alternate between effective communication with the medial entorhinal cortex and CA3, which have different roles in encoding and recall of memory.
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