ArticleInfection2014
Epidemiology and risk factors for severe respiratory syncytial virus infections requiring pediatric intensive care admission in Hong Kong children.
Article in Infection, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Children born preterm admitted to paediatric intensive care for bronchiolitis: a systematic review and meta-analysis.BMC pediatrics · 2023Pooled it
- Respiratory syncytial virus hospitalization and mortality: Systematic review and meta-analysis.Pediatric pulmonology · 2017Pooled it
- Cost-Effectiveness Analysis of Nirsevimab for Respiratory Syncytial Virus Disease Prevention in Newborns of Hong Kong.Influenza and other respiratory viruses · 2025Article
- Respiratory syncytial virus hospitalization costs, rates, and seasonality in Asia: a systematic review and meta-analysis.EClinicalMedicine · 2025Review
- Effects of pH alteration on respiratory syncytial virus in human airway epithelial cells.ERJ open research · 2023Article
- Respiratory syncytial virus-associated hospitalisation in children aged ≤5 years: a scoping review of literature from 2009 to 2021.ERJ open research · 2022Article
- Mortality in children hospitalised with respiratory syncytial virus infection in Singapore.Singapore medical journal · 2021Article
- Risk factors for hospitalized respiratory syncytial virus disease and its severe outcomes.Influenza and other respiratory viruses · 2020Article
- Isolation and Characterization of Clinical RSV Isolates in Belgium during the Winters of 2016-2018.Viruses · 2019Article
- Characteristics of severe RSV infection needing intensive care.European journal of pediatrics · 2018Article
- Causes and incidence of community-acquired serious infections among young children in south Asia (ANISA): an observational cohort study.Lancet (London, England) · 2018Observational
- Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children.Respirology (Carlton, Vic.) · 2018Article
- Particle and bioaerosol characteristics in a paediatric intensive care unit.Environment international · 2017Article
- Global respiratory syncytial virus-associated mortality in young children (RSV GOLD): a retrospective case series.The Lancet. Global health · 2017Article
- Respiratory syncytial virus (RSV) entry is inhibited by serine protease inhibitor AEBSF when present during an early stage of infection.Virology journal · 2017Article
- The potential influence of human parainfluenza viruses detected during hospitalization among critically ill patients in Kuwait, 2013-2015.Virology journal · 2017Article
- [Prediction of Severe Course in Infants with RSV Bronchiolitis under 6 Months. Spain].Revista espanola de salud publica · 2017Observational
- Clinical characteristics and risk factors of severe respiratory syncytial virus-associated acute lower respiratory tract infections in hospitalized infants.World journal of pediatrics : WJP · 2014Article
- Pattern of Viral Infections among Infants and Children Admitted to the Paediatric Intensive Care Unit at Sultan Qaboos University Hospital, Oman.Sultan Qaboos University medical journal · 2014Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRespiratory syncytial virus (RSV) is a common cause of lower respiratory tract infection in young children. However, there are limited data on severe RSV infection requiring pediatric intensive care unit (PICU) admission. This retrospective study described features of RSV-associated PICU admissions in Hong Kong and investigated factors for mortality and duration of PICU stay.
methodsChildren with laboratory-confirmed RSV infection and admitted to the PICUs of all eight government hospitals in Hong Kong between January 2009 and June 2011 were identified from computerized auditing systems and PICU databases. RSV in respiratory samples was detected by direct immunofluorescence and/or viral culture. The relationships between mortality and PICU duration and demographic and clinical factors were analyzed.
resultsA total of 118 (2.4 %) PICU admissions were identified among 4,912 RSV-positive pediatric cases in all hospitals. Sixty-five (55.6 %) patients were infants. PICU admissions were higher between October and March. Eight (6.8 %) patients died, but only two were infants. RSV-associated mortality was related to prior sick contact, presence of older siblings, neurodevelopmental conditions, chromosomal and genetic diseases, and bacterial co-infections, but none was significant following logistic regression analyses (odds ratio 9.36, 95 % confidence interval 0.91-96.03 for prior sick contact, p = 0.060). Chronic lung disease was the only risk factor for the duration of PICU admission (β = 0.218, p = 0.017).
conclusionsThe majority of RSV-infected children do not require PICU support. There is winter seasonality for RSV-associated PICU admission in Hong Kong. Prior sick contact is the only risk factor for RSV-associated mortality, whereas the presence of chronic lung disease is associated with longer PICU stay. The current risk-based approach of RSV prophylaxis may not be effective in reducing severe RSV infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.