Evidence map›Paper›PMID 24277457›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2014

Common and complex Notch1 mutations in Chinese oral squamous cell carcinoma.

Xiaomeng Song, Ronghui Xia, Jiang Li, Zhifeng Long, Hening Ren, Wantao Chen, Li Mao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

  1. Pooled it
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  15. Frontiers in immunology · 2022
    Article
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  18. Notch Signaling and Human Papillomavirus-Associated Oral Tumorigenesis.Advances in experimental medicine and biology · 2021
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Xiaomeng SongAuthors' Affiliations: Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology, Shanghai, China; Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry; Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore; and Personal Diagnostix Inc., Gaithersburg, Maryland.
Ronghui Xia
Jiang Li
Zhifeng Long
Hening Ren
Wantao Chen
Li Mao
University of Maryland, Baltimore · USShanghai Ninth People's Hospital · CN

Funding

UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FEYRUZ VIRGILIA RASSOOL · 2008 to 2026
$51.0M
HDGF: a novel biomarker and therapetic target of lung cancerR01CA126818 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MAO, LI · 2008 to 2012
$1.6M
NCI NIH HHS P30 CA134274NCI NIH HHS R01 CA126818
6 · The paper itself

Abstract

purposeTo determine Notch1 mutation status in oral squamous cell carcinoma (OSCC) from Chinese population and its potential clinical implications. EXPERIMENTAL

designSurgically resected OSCC tissues from 51 Chinese patients and 13 head and neck squamous cell carcinoma (HNSCC) cell lines were sequenced for mutations in the entire coding regions of Notch1 and TP53 using a next-generation sequencing platform. Sequences of the genes were also determined in corresponding normal tissues from 46 of the 51 patients. Mutations and their association with clinical parameters were analyzed.

resultsSix mutations in Notch1 and 11 mutations in TP53 coding regions were detected in 4 (31%) and 10 (77%) of the 13 HNSCC cell lines, respectively. Forty-two somatic Notch1 mutations, including 7 nonsense mutations and 11 mutations within the domain commonly harboring potential activating mutations in acute lymphoblastic leukemia, were detected in 22 (43%) of the 51 Chinese OSCC tumors. In comparison, 25 somatic TP53 mutations were observed in 21 (41%) of the 51 tumors. Patients whose tumors carried Notch1 mutation had significantly shorter overall and disease-free survivals (P = 0.004 and P = 0.001, respectively, by log-rank test) compared with those whose tumors carried no Notch1 mutation. Multivariate analysis showed that both Notch1 mutation and lymph node metastasis are independent prognostic factors in the patient population (P = 0.001). All 15 patients with both Notch1 mutation and nodal metastasis recurred or metastasized within 2 years after surgery.

conclusionsNotch1 mutation is common in Chinese OSCC and associates with clinical outcomes. The complexity of the mutation spectrum warrants further investigation of Notch1 in Chinese patients with OSCC.

Indexed as

MutationAdultAgedAsian PeopleCarcinoma, Squamous CellDNA Mutational AnalysisFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMouth NeoplasmsPrognosisReceptor, Notch1Reverse Transcriptase Polymerase Chain ReactionTumor Suppressor Protein p53NOTCH1 protein, humanReceptor, Notch1TP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID24277457
PMCPMC3946562
OpenAlexW2142134975

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.