ArticlePharmaceutical research2015
Tumor necrosis factor-related apoptosis inducing ligand gene polymorphisms are correlated with gastric cancer in central China.
Article in Pharmaceutical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- TRAIL C1595T Variant Critically Alters the Level of sTRAIL in Terms of Histopathological Parameters in Colorectal Cancer.Indian journal of clinical biochemistry : IJCB · 2024Article
- Effect of trail C1595T variant and gene expression on the pathogenesis of non-small cell lung cancer.The Libyan journal of medicine · 2019Article
- Association between breast cancer and tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) gene 1595C/T SNP in a Pakistani population.Contemporary oncology (Poznan, Poland) · 2016Article
- Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Gene Polymorphisms and Hepatitis B Virus Infection.Jundishapur journal of microbiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the association of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) gene polymorphisms with gastric cancer in Chinese Han population in central China.
methodsA total of 304 patients with gastric cancer confirmed by histopathology and 421 unrelated healthy controls were studied. Gene polymorphisms of TRAIL (G1525A and C1595T) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
resultsThe frequency of the genotype carriers of TRAIL 1525A (GA + AA) and 1595T (CT + TT) was significantly lower in gastric cancer than in healthy controls (37.2% vs. 61.5%, P < 0.001, OR = 0.581, 95% CI 0.442 ~ 0.764; 36.2% vs. 62.0%, P < 0.001, OR = 0.570, 95% CI 0.433 ~ 0.750, respectively). Stratification analysis showed that both TRAIL 1525A (GA + AA) and 1595T (CT + TT) carriers were associated with poorly-differentiated gastric cancer compared to 1525GG genotype and 1595CC genotype (OR = 0.516, 95%CI 0.279 ~ 0.957, P = 0.026; OR = 0.395, 95%CI 0.207 ~ 0.753, P = 0.004, respectively).
conclusionsTRAIL G1525A and C1595T gene polymorphisms were significantly correlated with the susceptibility to gastric cancer in Chinese Han population in central China.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.