ReviewAdvances in experimental medicine and biology2014
Revisiting Mortimer's Genome Renewal Hypothesis: heterozygosity, homothallism, and the potential for adaptation in yeast.
Review in Advances in experimental medicine and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Distinctive domestication of farmhouse beer yeasts preserved pre-industrial genetic and phenotypic diversity.Current biology : CB · 2026Article
- Genetic and phenotypic diversity of wine-associated Hanseniaspora species.FEMS yeast research · 2025Article
- Graph-Based Pan-Genome Reveals the Pattern of Deleterious Mutations during the Domestication ofJournal of fungi (Basel, Switzerland) · 2024Article
- Recombination, admixture and genome instability shape the genomic landscape of Saccharomyces cerevisiae derived from spontaneous grape ferments.PLoS genetics · 2024Article
- Whole genome sequencing of Canadian Saccharomyces cerevisiae strains isolated from spontaneous wine fermentations reveals a new Pacific West Coast Wine clade.G3 (Bethesda, Md.) · 2023Article
- Genome-scale patterns in the loss of heterozygosity incidence in Saccharomyces cerevisiae.Genetics · 2022Article
- The Ecology and Evolution of the Baker's YeastGenes · 2022Review
- Insights on life cycle and cell identity regulatory circuits for unlocking genetic improvement in Zygosaccharomyces and Kluyveromyces yeasts.FEMS yeast research · 2021Article
- Genome-wide mapping of spontaneous genetic alterations in diploid yeast cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- SUMO and cellular adaptive mechanisms.Experimental & molecular medicine · 2020Review
- Genome structure reveals the diversity of mating mechanisms inMicrobial genomics · 2020Article
- Baker's Yeast Clinical Isolates Provide a Model for How Pathogenic Yeasts Adapt to Stress.Trends in genetics : TIG · 2019Review
- Multiple Reinventions of Mating-type Switching during Budding Yeast Evolution.Current biology : CB · 2019Article
- Controlled Reduction of Genomic Heterozygosity in an Industrial Yeast Strain Reveals Wide Cryptic Phenotypic Variation.Frontiers in genetics · 2019Article
- The origin and adaptive evolution of domesticated populations of yeast from Far East Asia.Nature communications · 2018Article
- Brettanomyces bruxellensis population survey reveals a diploid-triploid complex structured according to substrate of isolation and geographical distribution.Scientific reports · 2018Article
- Genome Dynamics of HybridG3 (Bethesda, Md.) · 2017Article
- Pioneer cells established by the [SWI+] prion can promote dispersal and out-crossing in yeast.PLoS biology · 2017Article
- An Evolutionary Perspective on Yeast Mating-Type Switching.Genetics · 2017Review
- Social wasps are a Saccharomyces mating nest.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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Abstract
In diploid organisms, the frequency and nature of sexual cycles have a major impact on genome-wide patterns of heterozygosity. Recent population genomic surveys in the budding yeast, Saccharomyces cerevisiae, have revealed surprising levels of genomic heterozygosity in what has been traditionally considered a highly inbred organism. I review evidence and hypotheses regarding the generation, maintenance, and evolutionary consequences of genomic heterozygosity in S. cerevisiae. I propose that high levels of heterozygosity in S. cerevisiae, arising from population admixture due to human domestication, coupled with selfing during rare sexual cycles, can facilitate rapid adaptation to novel environments.
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