ArticleAntimicrobial agents and chemotherapy2014
Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- Gastrointestinal axis in post-traumatic sepsis: from molecular mechanisms to translational perspectives.Frontiers in immunology · 2026Review
- Antivirulence drugs against Acinetobacter baumannii: where do they stand?World journal of microbiology & biotechnology · 2025Review
- Should We Fiddle with Gut Microbiome in Critically Ill?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Review
- Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity.Nature communications · 2020Article
- Critical illness and the role of the microbiome.Acute medicine & surgery · 2019Review
- Gut integrity in critical illness.Journal of intensive care · 2019Review
- Surviving sepsis campaign: research priorities for sepsis and septic shock.Intensive care medicine · 2018Article
- Recent Anti-Microbial Exposure Is Associated with More Complications after Elective Surgery.Surgical infections · 2018Article
- Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
- Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.Frontiers in immunology · 2018Review
- The intestinal microenvironment in sepsis.Biochimica et biophysica acta. Molecular basis of disease · 2017Review
- De Novo Synthesis of Phosphorylated Triblock Copolymers with Pathogen Virulence-Suppressing Properties That Prevent Infection-Related Mortality.ACS biomaterials science & engineering · 2017Article
- Pathophysiology of the Gut and the Microbiome in the Host Response.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Review
- Critical role of microbiota within cecal crypts on the regenerative capacity of the intestinal epithelium following surgical stress.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Collapse of the Microbiome, Emergence of the Pathobiome, and the Immunopathology of Sepsis.Critical care medicine · 2017Article
- The Influence of Host Stress on the Mechanism of Infection: Lost Microbiomes, Emergent Pathobiomes, and the Role of Interkingdom Signaling.Frontiers in microbiology · 2017Article
- The gut microbiota and gastrointestinal surgery.Nature reviews. Gastroenterology & hepatology · 2017Review
- How do we make indoor environments and healthcare settings healthier?Microbial biotechnology · 2017Article
- Class I PI3-kinase or Akt inhibition do not impair axonal polarization, but slow down axonal elongation.Biochimica et biophysica acta · 2016Article
- Infection control in colon surgery.Langenbeck's archives of surgery · 2016Review
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
Abstract
Antibiotic resistance among highly pathogenic strains of bacteria and fungi is a growing concern in the face of the ability to sustain life during critical illness with advancing medical interventions. The longer patients remain critically ill, the more likely they are to become colonized by multidrug-resistant (MDR) pathogens. The human gastrointestinal tract is the primary site of colonization of many MDR pathogens and is a major source of life-threatening infections due to these microorganisms. Eradication measures to sterilize the gut are difficult if not impossible and carry the risk of further antibiotic resistance. Here, we present a strategy to contain rather than eliminate MDR pathogens by using an agent that interferes with the ability of colonizing pathogens to express virulence in response to host-derived and local environmental factors. The antivirulence agent is a phosphorylated triblock high-molecular-weight polymer (here termed Pi-PEG 15-20) that exploits the known properties of phosphate (Pi) and polyethylene glycol 15-20 (PEG 15-20) to suppress microbial virulence and protect the integrity of the intestinal epithelium. The compound is nonmicrobiocidal and appears to be highly effective when tested both in vitro and in vivo. Structure functional analyses suggest that the hydrophobic bis-aromatic moiety at the polymer center is of particular importance to the biological function of Pi-PEG 15-20, beyond its phosphate content. Animal studies demonstrate that Pi-PEG prevents mortality in mice inoculated with multiple highly virulent pathogenic organisms from hospitalized patients in association with preservation of the core microbiome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.