ArticleJAMA pediatrics2014
Trends in otitis media-related health care use in the United States, 2001-2011.
Article in JAMA pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pneumococcal conjugate vaccines for preventing acute otitis media in children.The Cochrane database of systematic reviews · 2020Pooled it
- Pneumococcal conjugate vaccines for preventing acute otitis media in children.The Cochrane database of systematic reviews · 2019Pooled it
- Influenza vaccines for preventing acute otitis media in infants and children.The Cochrane database of systematic reviews · 2017Pooled it
- Parental views on otitis media: systematic review of qualitative studies.European journal of pediatrics · 2016Pooled it
- Trial
- Cost of childhood acute otitis media in primary care in the Netherlands: economic analysis alongside a cluster randomised controlled trial.BMC health services research · 2021Trial
- A survey comparison of educational interventions for teaching pneumatic otoscopy to medical students.BMC medical education · 2019Trial
- Efficacy of 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine against acute otitis media and nasopharyngeal carriage in Panamanian children - A randomized controlled trial.Human vaccines & immunotherapeutics · 2017Trial
- Otitis Media With Effusion in Patients With Cleft Palate.Clinical pediatrics · 2026Review
- Systematic analysis of global trends in otitis media burden across Socio-Demographic Index levels, 1990-2021: findings from the global burden of disease study 2021.Frontiers in public health · 2026Article
- Influence of area-level social vulnerability on all-cause pneumonia, all-cause acute otitis media, and invasive pneumococcal disease incidence among Medicaid-enrolled children.Pneumonia (Nathan Qld.) · 2025Article
- PCV20 for the prevention of invasive pneumococcal disease in the Mexican pediatric population: A cost-effectiveness analysis.Human vaccines & immunotherapeutics · 2025Article
- Conceptual Methodological Framework for Incorporating Antimicrobial Resistance Considerations in Economic Models for Pneumococcal Conjugate Vaccines.Infectious diseases and therapy · 2025Article
- Interventions to Minimize Unnecessary Antibiotic Use for Acute Otitis Media: A Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- Otitis Media Trial Publication After ClinicalTrials.gov Registration.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Observational
- A population-based study on the burden of hospitalized pediatric pneumococcal disease in Taiwan before and after the introduction of 13-valent pneumococcal conjugate vaccine into the childhood immunization program in 2015.BMC infectious diseases · 2025Article
- Global burden of childhood otitis media attributable to secondhand smoke from 1990 to 2021: a systematic analysis of the global burden of disease study 2021.Frontiers in pediatrics · 2025Article
- Reduction of Antibiotic-Associated Conditions After Tympanostomy Tube Placement in Children.The Laryngoscope · 2025Article
- The Health and Economic Effects of PCV15 and PCV20 During the First Year of Life in the US.Vaccines · 2024Article
- Outpatient Visits and Antibiotic Use Due to Higher-Valency Pneumococcal Vaccine Serotypes.The Journal of infectious diseases · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
importanceOtitis media (OM) is a leading cause of pediatric health care visits and the most frequent reason children consume antibiotics or undergo surgery. During recent years, several interventions have been introduced aiming to decrease OM burden.
objectiveTo study the trend in OM-related health care use in the United States during the pneumococcal conjugate vaccine (PCV) era (2001-2011). DESIGN, SETTING, AND
participantsAn analysis of an insurance claims database of a large, nationwide managed health care plan was conducted. Enrolled children aged 6 years or younger with OM visits were identified. MAIN OUTCOMES AND MEASURES: Annual OM visit rates, OM-related complications, and surgical interventions were analyzed.
resultsOverall, 7.82 million unique children (5.51 million child-years) contributed 6.21 million primary OM visits; 52% were boys and 48% were younger than 2 years. There was a downward trend in OM visit rates from 2004 to 2011, with a significant drop that coincided with the advent of the 13-valent vaccine (PCV-13) in 2010. The observed OM visit rates in 2010 (1.00/child-year) and 2011 (0.81/child-year) were lower than the projected rates based on the 2005-2009 trend had there been no intervention (P < .001). Recurrent OM (≥3 OM visits within 6-month look-back) rates decreased at 0.003/child-year (95% CI, 0.002-0.004/child-year) in 2001-2009 and at 0.018/child-year (95% CI, 0.008-0.028/child-year) in 2010-2011. In the PCV-13 premarket years, there was a stable rate ratio (RR) between OM visit rates in children younger than 2 years and in those aged 2 to 6 years (RR, 1.38; 95% CI, 1.38-1.39); the RR decreased significantly (P < .001) during the transition year 2010 (RR 1.32; 95% CI, 1.31-1.33) and the postmarket year 2011 (RR 1.01; 95% CI, 1.00-1.02). Tympanic membrane perforation/otorrhea rates gradually increased (from 3721 per 100,000 OM child-years in 2001 to 4542 per 100,000 OM child-years in 2011; P < .001); the increase was significant only in the older children group. Mastoiditis rates substantially decreased (from 61 per 100,000 child-years in 2008 to 37 per 100,000 child-years in 2011; P < .001). Ventilating tube insertion rate decreased by 19% from 2010 to 2011 (P = .03). CONCLUSIONS AND RELEVANCE: There was an overall downward trend in OM-related health care use from 2001 to 2011. The significant reduction in OM visit rates in 2010-2011 in children younger than 2 years coincided with the advent of PCV-13. Although tympanic membrane perforation/otorrhea rates steadily increased during that period, mastoiditis and ventilating tube insertion rates decreased in the last years of the study.
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