Evidence map›Paper›PMID 24276017›Full record

ArticleInternational journal of obesity (2005)2014

Brain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants.

M G Hohenadel, M S Thearle, B A Grice, H Huang, M-H Dai, Y-X Tao, L A Hunter, G I Palaguachi, Z Mou, R C Kim and 12 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 1 country.

M G HohenadelNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Phoenix, AZ, USA.
M S ThearleNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Phoenix, AZ, USA.
B A GriceNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Phoenix, AZ, USA.
H HuangDepartment of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
M-H DaiDepartment of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
Y-X TaoDepartment of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
L A Hunter1] Unit on Metabolism and Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA [2] Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
G I Palaguachi1] Unit on Metabolism and Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA [2] Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
Z Mou1] Unit on Metabolism and Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA [2] Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
R C Kim1] Unit on Metabolism and Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA [2] Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
M M Tsang1] Unit on Metabolism and Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA [2] Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
K HaackDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
V S VorugantiDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
S A ColeDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
N F ButteUSDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA.
A G ComuzzieDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
Y L MullerNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Phoenix, AZ, USA.
L J BaierNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Phoenix, AZ, USA.
J KrakoffNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Phoenix, AZ, USA.
W C KnowlerNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Phoenix, AZ, USA.
J A YanovskiSection on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
J C Han1] Unit on Metabolism and Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA [2] Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Institute of Diabetes and Digestive and Kidney Diseases · USTexas Biomedical Research Institute · USAuburn University · USChildren's Nutrition Research Center at Baylor College of Medicine · USNational Institutes of Health · US

Funding

Physiology, Psychology, and Genetics of ObesityZIAHD000641 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YANOVSKI, JACK A. · 2009 to 2025
$24.8M
Structural Analysis Of Candidate Genes For Type 2 Diabetes and ObesityZIADK069071 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI BAIER, LESLIE J · 2009 to 2025
$15.4M
Genetic Epidemiology of Diabetes and ObesityZIADK069028 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HANSON, ROBERT · 2009 to 2025
$7.5M
Risk Factors and Etiology of Obesity and Type 2 DiabetesZIADK069015 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRAKOFF, JONATHAN · 2009 to 2025
$4.2M
Epidemiology of Type 2 Diabetes Mellitus in the Gila River Indian CommunityZIADK069000 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KNOWLER, WILLIAM C · 2009 to 2021
$3.4M
EXTRAMULAR RESEARCH FACILITIES CONSTRUCTIONC06RR017515 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI SHADE, ROBERT E · 2003 to 2003
$3.1M
GENETICS OF CHILDHOOD OBESITYR01DK059264 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI BUTTE, NANCY F · 2000 to 2004
$2.7M
Obesity and Diabetes Familial Risk in Hispanic ChildrenR01DK080457 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI BUTTE, NANCY F. · 2009 to 2012
$2.5M
Neuroendocrine Regulation of Metabolism and NeurocognitionZIAHD008898 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI HAN, JOAN C. · 2010 to 2014
$1.4M
MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATIONC06RR013556 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI SHADE, ROBERT E · 1998 to 1998
–
Intramural NIH HHS ZIA HD008898NCRR NIH HHS C06 RR013556NCRR NIH HHS C06 RR017515NIDDK NIH HHS R01 DK059264NIDDK NIH HHS R01 DK080457NIDDK NIH HHS R01 DK59264
6 · The paper itself

Abstract

backgroundIn rodents, hypothalamic brain-derived neurotrophic factor (BDNF) expression appears to be regulated by melanocortin-4 receptor (MC4R) activity. The impact of MC4R genetic variation on circulating BDNF in humans is unknown.

objectiveThe objective of this study is to compare BDNF concentrations of subjects with loss-of-function (LOF) and gain-of-function (GOF) MC4R variants with those of controls with common sequence MC4R.

methodsCirculating BDNF was measured in two cohorts with known MC4R sequence: 148 subjects of Pima Indian heritage ((mean±s.d.): age, 15.7±6.5 years; body mass index z-scores (BMI-Z), 1.63±1.03) and 69 subjects of Hispanic heritage (10.8±3.6 years; BMI-Z, 1.57±1.07). MC4R variants were characterized in vitro by cell surface expression, receptor binding and cyclic AMP response after agonist administration. BDNF single-nucleotide polymorphisms (SNPs) rs12291186, rs6265 and rs7124442 were also genotyped.

resultsIn the Pima cohort, no significant differences in serum BDNF was observed for 43 LOF subjects versus 65 LOF-matched controls (age, sex and BMI matched; P=0.29) or 20 GOF subjects versus 20 GOF-matched controls (P=0.40). Serum BDNF was significantly associated with genotype for BDNF rs12291186 (P=0.006) and rs6265 (P=0.009), but not rs7124442 (P=0.99); BDNF SNPs did not interact with MC4R status to predict serum BDNF. In the Hispanic cohort, plasma BDNF was not significantly different among 21 LOF subjects, 20 GOF subjects and 28 controls (P=0.79); plasma BDNF was not predicted by BDNF genotype or BDNF-x-MC4R genotype interaction.

conclusionsCirculating BDNF concentrations were not significantly associated with MC4R functional status, suggesting that peripheral BDNF does not directly reflect hypothalamic BDNF secretion and/or that MC4R signaling is not a significant regulator of the bulk of BDNF expression in humans.

Indexed as

Hispanic or LatinoIndians, North AmericanPolymorphism, Single NucleotideAdolescentAdultArizonaBrain-Derived Neurotrophic FactorChildChild, PreschoolCohort StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansHypothalamusLongitudinal StudiesBDNF protein, humanBrain-Derived Neurotrophic FactorMC4R protein, humanReceptor, Melanocortin, Type 4

Identifiers

PMID24276017
PMCPMC4033711
OpenAlexW2043249788

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.