Evidence map›Paper›PMID 24275957›Full record

SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2015

Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration.

G Filardo, E Kon, A Roffi, B Di Matteo, M L Merli, M Marcacci

3 registry-linked trialsOpen access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 123 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 14 pooled it
16.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02135367 nacompletednot on this map

Platelet-rich Plasma (PRP) vs Viscosupplementation for the Treatment of Early Knee Articular Degenerative Pathology: a Randomized Double-blind Controlled Trial

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2013 to 2018Enrolled185ConditionsKnee Chondropathy, Knee Early OsteoarthritisArmsPRP
NCT02872753 phase4completednot on this mapstarted 2017, after this paper: background citation

Intra-operative ACP Injection Following Partial Meniscectomy: a Randomized Controlled Trial

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2017 to 2023Enrolled90ConditionsMeniscectomyArmsACP, Standard Meniscectomy
NCT04222140 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Early Regenerative Intervention for Post-Traumatic Osteoarthritis

TypeinterventionalSponsorAffinity Health Research InstituteRan2020 to 2021Enrolled40ConditionsPost-Traumatic Osteoarthritis of KneeArmsERIPTO Protocol, BMAC Only
3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 14 syntheses or guidelines pooled it, 260 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Platelet-rich plasma in tendon-related disorders: results and indications.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018
    Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

G FilardoNano-Biotechnology Laboratory, II Orthopaedic Clinic, Rizzoli Orthopaedic Insitute, Via di Barbiano n. 1/10, 40136, Bologna, Italy.
E Kon
A Roffi
B Di Matteo
M L Merli
M Marcacci
Orthopedic Institute · USIstituto Ortopedico Rizzoli · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this review was to analyze the available evidence on the clinical application of this biological approach for the injective treatment of cartilage lesions and joint degeneration, together with preclinical studies to support the rationale for the use of platelet concentrates, to shed some light and give indications on what to treat and what to expect from intra-articular injections of platelet-rich plasma (PRP).

methodsAll in vitro, in vivo preclinical and clinical studies on PRP injective treatment in the English language concerning the effect of PRP on cartilage, synovial tissue, menisci, and mesenchymal stem cells were considered. A systematic review on the PubMed database was performed using the following words: (platelet-rich plasma or PRP or platelet concentrate or platelet lysate or platelet supernatant) and (cartilage or chondrocytes or synoviocytes or menisci or mesenchymal stem cells).

resultsFifty-nine articles met the inclusion criteria: 26 were in vitro, 9 were in vivo, 2 were both in vivo and in vitro, and 22 were clinical studies. The analysis showed an increasing number of published studies over time. Preclinical evidence supports the use of PRP injections that might promote a favourable environment for joint tissues healing. Only a few high-quality clinical trials have been published, which showed a clinical improvement limited over time and mainly documented in younger patients not affected by advanced knee degeneration.

conclusionsBesides the limits and sometimes controversial findings, the preclinical literature shows an overall support toward this PRP application. An intra-articular injection does not just target cartilage; instead, PRP might influence the entire joint environment, leading to a short-term clinical improvement. Many biological variables might influence the clinical outcome and have to be studied to optimize PRP injective treatment of cartilage degeneration and osteoarthritis.

Indexed as

Orthopedic ProceduresPlatelet-Rich PlasmaCartilage DiseasesHumansInjections, Intra-ArticularOsteoarthritis

Identifiers

PMID24275957
PMCPMC4541701
OpenAlexW2073305164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.