ArticlePharmaceuticals (Basel, Switzerland)2013
The use of central nervous system active drugs during pregnancy.
Article in Pharmaceuticals (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 7 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Association between gestational hypnotic benzodiazepine receptor agonists exposure and adverse pregnancy outcomes: a systematic review and meta-analysis.Archives of women's mental health · 2025Pooled it
- Opioid exposure during pregnancy and the risk of congenital malformation: a meta-analysis of cohort studies.BMC pregnancy and childbirth · 2022Pooled it
- Pregnancy and Delivery Outcomes Following Benzodiazepine Exposure: A Systematic Review and Meta-analysis.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Pooled it
- Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis.Orphanet journal of rare diseases · 2018Pooled it
- Maternal Use of Opioids During Pregnancy and Congenital Malformations: A Systematic Review.Pediatrics · 2017Pooled it
- Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes.BMC medicine · 2017Pooled it
- Obstetric and neonatal outcomes after antipsychotic medication exposure in pregnancy.Obstetrics and gynecology · 2015Pooled it
- Prenatal Prescription Opioid Analgesic Exposure and Academic Performance in Third Grade Children: A Population-Based Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Maternal opioid use disorder and hepatitis C infection in pregnancy reshape the peripheral immune landscape at term.EBioMedicine · 2026Article
- Association between prenatal opioid exposure and long-term neurodevelopmental disorders among children: a nationwide cohort study : Prenatal opioid exposure and neurodevelopment.BMC pediatrics · 2026Article
- Analgesic opioids in pregnancy and placental malperfusion-related disorders: a population-based cohort study.International journal of epidemiology · 2025Article
- Risk of adverse obstetrical and neonatal outcomes in women consuming recreational drugs during pregnancy.BMC pregnancy and childbirth · 2025Observational
- Prenatal Opioid Use Disorder and the Risk of Congenital Anomalies in Offspring: A Population-Based Study.Birth defects research · 2025Article
- Maternal, Fetal, and Neonatal Outcomes of Opioid-Dependent Mothers in Iran: A case Study of Iran.Addiction & health · 2025Article
- Maternal mental disorders, psychotropic drugs, socioeconomic status, and offspring congenital anomalies.The Journal of international medical research · 2025Article
- Investigating maternal and neonatal health outcomes associated with continuing or ceasing dexamphetamine treatment for women with attention-deficit hyperactivity disorder during pregnancy: a retrospective cohort study.Archives of women's mental health · 2024Article
- Timing of treatment for opioid use disorder among birthing people.Journal of substance use and addiction treatment · 2024Article
- Management of status epilepticus in pregnancy: a clinician survey.Neurological research and practice · 2024Article
- Nutritional Status Differs by Prescription Opioid Use among Women of Reproductive Age: NHANES 1999-2018.Nutrients · 2023Article
- Association of In Utero Antipsychotic Medication Exposure With Risk of Congenital Malformations in Nordic Countries and the US.JAMA psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CNS-active drugs are used relatively often during pregnancy. Use during early pregnancy may increase the risk of a congenital malformation; use during the later part of pregnancy may be associated with preterm birth, intrauterine growth disturbances and neonatal morbidity. There is also a possibility that drug exposure can affect brain development with long-term neuropsychological harm as a result. This paper summarizes the literature on such drugs used during pregnancy: opioids, anticonvulsants, drugs used for Parkinson's disease, neuroleptics, sedatives and hypnotics, antidepressants, psychostimulants, and some other CNS-active drugs. In addition to an overview of the literature, data from the Swedish Medical Birth Register (1996-2011) are presented. The exposure data are either based on midwife interviews towards the end of the first trimester or on linkage with a prescribed drug register. An association between malformations and maternal use of anticonvulsants and notably valproic acid is well known from the literature and also demonstrated in the present study. Some other associations between drug exposure and outcome were found.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.