ReviewCurrent opinion in endocrinology, diabetes, and obesity2014
Endocrinology of anorexia nervosa in young people: recent insights.
Review in Current opinion in endocrinology, diabetes, and obesity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Pooled it
- Psychological aspects of infertility. A systematic review.The Journal of international medical research · 2020Pooled it
- Aspergillosis in anorexia nervosa: a report of two cases and review of the literature.BMC infectious diseases · 2026Review
- Patterns and trends of eating disorders among women of childbearing age: a comprehensive analysis from 1990 to 2021 with future predictions.Eating and weight disorders : EWD · 2026Article
- Therapeutic approaches for endocrine dysregulation in anorexia nervosa in adolescents.Frontiers in pediatrics · 2026Review
- Reversibility of disturbed pituitary function in pediatric conditions with psychological stressors: implications for clinical practice.Hormones (Athens, Greece) · 2024Review
- Trajectory of ghrelin and PYY around a test meal in males and females with avoidant/restrictive food intake disorder versus healthy controls.Psychoneuroendocrinology · 2024Article
- Lower Ghrelin Levels Are Associated With Higher Anxiety Symptoms in Adolescents and Young Adults With Avoidant/Restrictive Food Intake Disorder.The Journal of clinical psychiatry · 2023Article
- Food Restriction in Mice Induces Food-Anticipatory Activity and Circadian-Rhythm-Related Activity Changes.Nutrients · 2022Article
- The Effects of Nutrition on Linear Growth.Nutrients · 2022Review
- Ghrelin as a possible biomarker and maintaining factor in patients with eating disorders reporting childhood traumatic experiences.European eating disorders review : the journal of the Eating Disorders Association · 2021Article
- Ghrelin and PYY in low-weight females with avoidant/restrictive food intake disorder compared to anorexia nervosa and healthy controls.Psychoneuroendocrinology · 2021Article
- The Synergistic Effects of a Complementary Physiotherapeutic Scheme in the Psychological and Nutritional Treatment in a Teenage Girl with Type 1 Diabetes Mellitus, Anxiety Disorder and Anorexia Nervosa.Children (Basel, Switzerland) · 2021Article
- An empirical examination of appetite hormones and cognitive and behavioral bulimic symptomatology.Eating and weight disorders : EWD · 2021Article
- Activity-Based Anorexia Induces Browning of Adipose Tissue Independent of Hypothalamic AMPK.Frontiers in endocrinology · 2021Article
- Brain Volume Loss, Astrocyte Reduction, and Inflammation in Anorexia Nervosa.Advances in neurobiology · 2021Article
- Interaction Network Prediction and Analysis of Anorexia Nervosa.Iranian journal of child neurology · 2019Article
- MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update.European journal of endocrinology · 2019Review
- Can growth hormone treatment improve growth in children with severe growth failure due to anorexia nervosa? A preliminary pilot study.Endocrine connections · 2017Article
- Obstetric and gynecologic problems associated with eating disorders.The International journal of eating disorders · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewAnorexia nervosa is among the most prevalent chronic medical conditions in young adults. It has acute as well as long-term consequences, some of which, such as low bone mineral density (BMD), are not completely reversible even after weight restoration. This review discusses our current understanding of endocrine consequences of anorexia nervosa. RECENT
findingsAnorexia nervosa is characterized by changes in multiple neuroendocrine axes including acquired hypogonadotropic hypogonadism, growth hormone resistance with low insulin-like growth factor-1 (likely mediated by fibroblast growth factor-1), relative hypercortisolemia, alterations in adipokines such as leptin, adiponectin and resistin, and gut peptides including ghrelin, PYY and amylin. These changes in turn contribute to low BMD. Studies in anorexia nervosa have demonstrated abnormalities in bone microarchitecture and strength, and an association between increased marrow fat and decreased BMD. One study in adolescents reported an improvement in BMD following physiologic estrogen replacement, and another in adults demonstrated improved BMD following risedronate administration. Brown adipose tissue is reduced in anorexia nervosa, consistent with an adaptive response to the energy deficit state. SUMMARY: Anorexia nervosa is associated with widespread physiologic adaptations to the underlying state of undernutrition. Hormonal changes in anorexia nervosa affect BMD adversely. Further investigation is underway to optimize therapeutic strategies for low BMD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.