ArticleNucleic acids research2014
Structural determinants of DNA recognition by plant MADS-domain transcription factors.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Fruit-Specific Promoters in Plants: Advances, Regulatory Mechanisms and Applications in Plant Biotechnology.Plants (Basel, Switzerland) · 2026Review
- A novel role of BPCs in the control of medial domain differentiation during gynoecium development in Arabidopsis thaliana.Plant molecular biology · 2025Article
- Promoter Motif Profiling and Binding Site Distribution Analysis of Transcription Factors Predict Auto- and Cross-Regulatory Mechanisms inInternational journal of molecular sciences · 2025Article
- G1-mediated OsMADS1 repression regulates sterile lemma development in rice.Plant cell reports · 2025Article
- Reflections on the ABC model of flower development.The Plant cell · 2024Review
- MADS8 is indispensable for female reproductive development at high ambient temperatures in cereal crops.The Plant cell · 2023Article
- Antagonistic regulation of target genes by the SISTER OF TM3-JOINTLESS2 complex in tomato inflorescence branching.The Plant cell · 2023Article
- Cracking the Floral Quartet Code: How Do Multimers of MIKCInternational journal of molecular sciences · 2023Review
- Dual specificity and target gene selection by the MADS-domain protein FRUITFULL.Nature plants · 2023Article
- Flower Development in Arabidopsis.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Excess nitrogen responsive HvMADS27 transcription factor controls barley root architecture by regulating abscisic acid level.Frontiers in plant science · 2022Article
- MADS1 maintains barley spike morphology at high ambient temperatures.Nature plants · 2021Article
- DNA-binding properties of the MADS-domain transcription factor SEPALLATA3 and mutant variants characterized by SELEX-seq.Plant molecular biology · 2021Article
- Multiple levels of crosstalk in hormone networks regulating plant defense.The Plant journal : for cell and molecular biology · 2021Review
- Review
- Genome-wide binding of SEPALLATA3 and AGAMOUS complexes determined by sequential DNA-affinity purification sequencing.Nucleic acids research · 2020Article
- Landscape of DNA binding signatures of myocyte enhancer factor-2B reveals a unique interplay of base and shape readout.Nucleic acids research · 2020Article
- Comparative analysis of binding patterns of MADS-domain proteins in Arabidopsis thaliana.BMC plant biology · 2018Article
- MADS transcription factors cooperate: complexities of complex formation.Journal of experimental botany · 2018Article
- Divergence of regulatory networks governed by the orthologous transcription factors FLC and PEP1 in Brassicaceae species.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant MADS-domain transcription factors act as key regulators of many developmental processes. Despite the wealth of information that exists about these factors, the mechanisms by which they recognize their cognate DNA-binding site, called CArG-box (consensus CCW6GG), and how different MADS-domain proteins achieve DNA-binding specificity, are still largely unknown. We used information from in vivo ChIP-seq experiments, in vitro DNA-binding data and evolutionary conservation to address these important questions. We found that structural characteristics of the DNA play an important role in the DNA binding of plant MADS-domain proteins. The central region of the CArG-box largely resembles a structural motif called 'A-tract', which is characterized by a narrow minor groove and may assist bending of the DNA by MADS-domain proteins. Periodically spaced A-tracts outside the CArG-box suggest additional roles for this structure in the process of DNA binding of these transcription factors. Structural characteristics of the CArG-box not only play an important role in DNA-binding site recognition of MADS-domain proteins, but also partly explain differences in DNA-binding specificity of different members of this transcription factor family and their heteromeric complexes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.