Evidence map›Paper›PMID 24275433›Full record

ArticleHeart rhythm2014

Autonomic nerve activity and blood pressure in ambulatory dogs.

Jessica Hellyer, A George Akingba, Kyoung-Suk Rhee, Alex Y Tan, Kathleen A Lane, Changyu Shen, Jheel Patel, Michael C Fishbein, Peng-Sheng Chen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Bradycardia-induced transient myocardial dysfunction in 3 dogs.The Canadian veterinary journal = La revue veterinaire canadienne · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jessica HellyerDivision of Cardiology, Department of Medicine, Krannert Institute of Cardiology, Indianapolis, Indiana.
A George AkingbaDivision of Cardiology, Department of Medicine, Krannert Institute of Cardiology, Indianapolis, Indiana; Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Kyoung-Suk RheeDivision of Cardiology, Department of Medicine, Krannert Institute of Cardiology, Indianapolis, Indiana.
Alex Y TanHunter Holmes McGuire VA Medical Center, Virginia Commonwealth University, Richmond, Virginia.
Kathleen A LaneDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana.
Changyu ShenDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana; Fairbanks School of Public Health, School of Medicine, Indiana University, Indianapolis, Indiana.
Jheel PatelDivision of Cardiology, Department of Medicine, Krannert Institute of Cardiology, Indianapolis, Indiana.
Michael C FishbeinDivision of Cardiology, Department of Medicine, Krannert Institute of Cardiology, Indianapolis, Indiana; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California.
Peng-Sheng ChenDivision of Cardiology, Department of Medicine, Krannert Institute of Cardiology, Indianapolis, Indiana. Electronic address: chenpp@iu.edu.
Indiana University – Purdue University Indianapolis · USHunter Holmes McGuire VA Medical Center · USIndiana University School of Medicine

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
WAVE DYNAMICS IN NORMAL AND DISEASED RABBIT HEARTSP01HL078931 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEISS, JAMES · 2005 to 2015
$20.7M
Thoracic Veins and Sustained Atrial FibrillationR01HL071140 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CHEN, PENG-SHENG · 2002 to 2014
$4.7M
Interactive Vagal Stimulation and Atrial FibrillationR21HL106554 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI LIN, SHIEN-FONG · 2011 to 2012
$424k
NCATS NIH HHS UL1 TR001108NHLBI NIH HHS P01 HL078931NHLBI NIH HHS P01HL78931NHLBI NIH HHS R01 HL071140NHLBI NIH HHS R01HL71140NHLBI NIH HHS R21 HL106554NHLBI NIH HHS R21HL106554
6 · The paper itself

Abstract

backgroundThe relationship between cardiac autonomic nerve activity and blood pressure (BP) changes in ambulatory dogs is unclear.

objectiveThe purpose of this study was to test the hypotheses that simultaneous termination of stellate ganglion nerve activity (SGNA) and vagal nerve activity (VNA) predisposes to spontaneous orthostatic hypotension and that specific β₂-adrenoceptor blockade prevents the hypotensive episodes.

methodsWe used a radiotransmitter to record SGNA, VNA, and BP in eight ambulatory dogs. Video imaging was used to document postural changes.

resultsOf these eight dogs, five showed simultaneous sympathovagal discharges in which the minute-by-minute integrated SGNA correlated with integrated VNA in a linear pattern (group 1). In these dogs, abrupt termination of simultaneous SGNA-VNA at the time of postural changes (as documented by video imaging) was followed by abrupt (>20 mm Hg over four beats) drops in BP. Dogs without simultaneous on/off firing (group 2) did not have drastic drops in pressure. ICI-118,551 (ICI, a specific β₂-blocker) infused at 3 µg/kg/h for 7 days significantly increased BP from 126 mm Hg (95% confidence interval 118-133) to 133 mm Hg (95% confidence interval 125-141; P = .0001). The duration of hypotension (mean systolic BP <100 mm Hg) during baseline accounted for 7.1% of the recording. The percentage was reduced by ICI to 1.3% (P = .01).

conclusionAbrupt simultaneous termination of SGNA-VNA was observed at the time of orthostatic hypotension in ambulatory dogs. Selective β₂-adrenoceptor blockade increased BP and reduced the duration of hypotension in this model.

Indexed as

Adrenergic beta-2 Receptor AntagonistsAnimalsAutonomic Nervous SystemBlood PressureDogsFemaleHeartHypotension, OrthostaticMaleStellate GanglionVagus NerveAdrenergic beta-2 Receptor AntagonistsAmbulatory nerve recordingANSautonomic nervous systemBeta-blockadeblood pressureBPheart rateHRintegrated stellate ganglion nerve activityintegrated vagal nerve activityiSGNAiVNAMSNAmuscle sympathetic nerve activityOrthostatic hypotensionSGNAstellate ganglion nerve activityvagal nerve activityVNA

Identifiers

PMID24275433
PMCPMC3918428
OpenAlexW1980232275

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.