ArticleNeuroscience2014
Nucleus accumbens core lesions enhance two-way active avoidance.
Article in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Article
- Basal Ganglia Output Has a Permissive Non-Driving Role in a Signaled Locomotor Action Mediated by the Midbrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance.eLife · 2020Article
- Circuits That Mediate Expression of Signaled Active Avoidance Converge in the Pedunculopontine Tegmentum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Contributions of medial prefrontal cortex to decision making involving risk of punishment.Neuropharmacology · 2018Article
- The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm.Molecular psychiatry · 2017Review
- Neurophysiology of Reward-Guided Behavior: Correlates Related to Predictions, Value, Motivation, Errors, Attention, and Action.Current topics in behavioral neurosciences · 2016Review
- Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum.Frontiers in behavioral neuroscience · 2015Article
- From ventral-medial to dorsal-lateral striatum: neural correlates of reward-guided decision-making.Neurobiology of learning and memory · 2015Review
- Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The majority of work examining the nucleus accumbens core (NAc) has focused on functions pertaining to behaviors guided by appetitive outcomes. These studies have pointed to the NAc as being critical for motivating behavior toward desirable outcomes. For example, we have recently shown that lesions of the NAc impaired performance on a reward-guided decision-making task that required rats to choose between differently valued rewards. Unfortunately, much less is known about the role that the NAc plays in motivating behavior when aversive outcomes are predicted. To address this issue we asked if NAc lesions impact performance on a two-way active avoidance task in which rats must learn to shuttle back and forth in a behavioral training box in order to avoid a footshock predicted by an auditory tone. Although bilateral NAc lesions initially impaired reward-guided decision-making, we found that the same lesions improved acquisition and retention of two-way active avoidance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.