Evidence map›Paper›PMID 24275306›Full record

ReviewHeart failure clinics2014

Heart failure in congenital heart disease: a confluence of acquired and congenital.

Akl C Fahed, Amy E Roberts, Seema Mital, Neal K Lakdawala

Abstract readReview
In one paragraph

Review in Heart failure clinics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Article
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  6. Review
  7. Epigenetics in Heart Failure.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Review
  10. Environmental changes surrounding congenital heart disease.Clinical and experimental pediatrics · 2023
    Article
  11. Review
  12. Article
  13. Article
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  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Akl C FahedDepartment of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Amy E Roberts
Seema Mital
Neal K Lakdawala
Boston Children's Hospital · USHarvard University · USUniversity of Toronto · CAVA Boston Healthcare System · US

Funding

GENOMICS OF CARDIOVASCULAR DEVELOPMENT, ADAPTIONU01HL066582 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SEIDMAN, JONATHAN G · 2000 to 2004
$14.9M
NHLBI NIH HHS U01 HL066582
6 · The paper itself

Abstract

Heart failure (HF) is a common cause of morbidity and mortality in congenital heart disease (CHD), with increasing prevalence because of improved treatment options and outcomes. Genetic factors and acquired postnatal factors in CHD might play a major role in the progression to HF. This article proposes 3 routes that lead to HF in CHD: rare monogenic entities that cause both CHD and HF; severe CHD lesions in which acquired hemodynamic effects of CHD or surgery result in HF; and, most commonly, a combined effect of complex genetics in overlapping pathways and acquired stressors caused by the primary lesion.

Indexed as

Heart Defects, CongenitalHeart FailureTherapies, InvestigationalAdultDisease ManagementDisease ProgressionEpigenomicsGene-Environment InteractionGenetic Association StudiesGenetic Predisposition to DiseaseHemodynamicsHumansPrecision MedicineAdultCongenital heart diseaseGenomicsHeart failure

Identifiers

PMID24275306
PMCPMC3874878
OpenAlexW177499201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.