Observational studyThe journal of pain2013
General health status and incidence of first-onset temporomandibular disorder: the OPPERA prospective cohort study.
Observational study in The journal of pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Prevalence of temporomandibular disorder in irritable bowel syndrome (IBS) patients: a systematic review.Journal of oral & facial pain and headache · 2025Pooled it
- Behavioral Modification as a Putative Mediator of Digital Therapeutic Response in Temporomandibular Disorders: Secondary Analysis of a Multicenter Sham-Controlled Randomized Trial.JMIR mHealth and uHealth · 2026Trial
- Exploring the Role of Negative Cognitions in the Relationship Between Ethnicity, Sleep, and Pain in Women With Temporomandibular Joint Disorder.The journal of pain · 2018Trial
- Comorbidities and associated factors of painful temporomandibular disorder symptoms in the BigMouth Dental Data Repository.Pain reports · 2026Article
- Comorbidities in Patients with Acute and Chronic Temporomandibular Disorders: An Exploratory Retrospective Study with a Conceptual Interdisciplinary Assessment Framework.Healthcare (Basel, Switzerland) · 2026Article
- Temporomandibular disorders-related symptoms and associated comorbidities in children and adolescents: A BigMouth data repository cross-sectional study.Cranio : the journal of craniomandibular practice · 2026Article
- The power to adapt: How resilience and changing expectations contribute to placebo effects.The journal of pain · 2026Article
- Biopsychosocial Predictors of Pain Persistence and Pain Chronification in Temporomandibular Disorders: A Systematic Review.Journal of clinical medicine · 2026Review
- Concomitant Headache and Its Association With Worse Psychological and Clinical Status in Temporomandibular Disorders.Journal of oral rehabilitation · 2026Article
- The Translational Biology of Temporomandibular Disorder Pain: Mechanisms, Biomarkers, and Therapeutic Perspectives.Journal of pain research · 2026Review
- Pre-natal nutrition as risk factor for painful temporomandibular disorders and headaches in young adults.Headache · 2026Article
- The Role of Stress in Burning Mouth Syndrome Triggered by Dental Treatments: A Two-Step Hypothesis.Journal of oral rehabilitation · 2025Article
- Rome Foundation Working Team Report on overlap in disorders of gut-brain interaction.Nature reviews. Gastroenterology & hepatology · 2025Review
- Association Between Temporomandibular Disorders and Irritable Bowel Syndrome: A Scoping Review.Journal of clinical medicine · 2024Article
- Prevalence of psychosocial findings and their correlation with TMD symptoms in an adult population sample.Progress in orthodontics · 2024Article
- Elevated pain sensitivity is associated with reduced rapid eye movement (REM) sleep in females with comorbid temporomandibular disorder and insomnia.Pain medicine (Malden, Mass.) · 2024Article
- Article
- Genetically predicted major depression causally increases the risk of temporomandibular joint disorders.Frontiers in genetics · 2024Article
- Perspective: Advancing the science regarding temporomandibular disorders.Frontiers in dental medicine · 2024Article
- Prevalence of Temporomandibular Disorders Based on a Shortened Symptom Questionnaire of the Diagnostic Criteria for Temporomandibular Disorders and Its Screening Reliability for Children and Adolescents Aged 7-14 Years.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
unlabelledTemporomandibular disorder (TMD) overlaps with other health conditions, but no study has examined which of these conditions increase the risk of developing first-onset TMD. The authors prospectively evaluated the relationship between health status at enrollment and subsequent incidence of TMD in 2,722 men and women. Participants aged 18 to 44 years had no history of TMD and were clinically free of TMD when enrolled in 2006 to 2008 at 4 U.S. study sites in the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) prospective cohort study. First-onset examiner-classified TMD developed in 260 people over a median 2.8 years of follow-up. Cox regression estimated the association between health conditions and TMD incidence while accounting for potential confounders. Incidence of first-onset TMD was 50% higher for people with low back pain (adjusted hazard ratio [AHR] = 1.50, 95% confidence limits [CLs]: 1.08, 2.10) and 75% higher for people with genital pain symptoms (AHR = 1.75, 95% CLs = 1.04, 2.93) than people without a history of these pain disorders. Digit ratio, a marker of intrauterine exposure to sex hormones, was significantly associated with TMD incidence. Other independent predictors of first-onset TMD were sleep disturbance and cigarette smoking. These findings reveal multiple influences of health status on incidence of first-onset TMD. PERSPECTIVE: This article examines health conditions that commonly overlap with TMD to determine which ones predict first-onset TMD. A history of low back pain and genital pain conditions at baseline were important predictors. Novel findings were that disrupted sleep and conditions in utero may increase incidence of first-onset TMD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.