Evidence map›Paper›PMID 24275061›Full record

ArticleJournal of neuroimmunology2014

IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination.

Aya D Pusic, Kae M Pusic, Benjamin L L Clayton, Richard P Kraig

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.

  1. Pooled it
  2. Investigating theResearch in pharmaceutical sciences · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Vesicles: New Advances in the Treatment of Neurodegenerative Diseases.International journal of molecular sciences · 2024
    Review
  9. Review
  10. Review
  11. Extracellular Vesicle-Mediated Neuron-Glia Communications in the Central Nervous System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
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  20. Review

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Aya D PusicDepartment of Neurology, The University of Chicago, Chicago, IL 60637, USA; Committee on Neurobiology, The University of Chicago, Chicago, IL 60637, USA.
Kae M PusicDepartment of Neurology, The University of Chicago, Chicago, IL 60637, USA.
Benjamin L L ClaytonDepartment of Neurology, The University of Chicago, Chicago, IL 60637, USA; Committee on Neurobiology, The University of Chicago, Chicago, IL 60637, USA.
Richard P KraigDepartment of Neurology, The University of Chicago, Chicago, IL 60637, USA; Committee on Neurobiology, The University of Chicago, Chicago, IL 60637, USA. Electronic address: rkraig@neurology.bsd.uchicago.edu.
University of Chicago · US

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
THE MOLECULAR BASIS OF B-MANNOSIDOSISP01HD009402 · NICHD · UNIVERSITY OF CHICAGO · PI KRAIG, RICHARD P · 1985 to 2015
$13.0M
HYDROGEN IONS AND BRAIN INFARCTIONR01NS019108 · NINDS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI KRAIG, RICHARD P · 1985 to 2019
$5.2M
TRAINING IN NEURAL SYSTEMST32GM007839 · NIGMS · UNIVERSITY OF CHICAGO · PI MASON, PEGGY · 1985 to 2012
$4.2M
Exosome RNA-Therapeutics to Promote CNS MyelinationUH3TR000918 · NCATS · UNIVERSITY OF CHICAGO · PI KRAIG, RICHARD P · 2015 to 2017
$1.1M
Exosome RNA-Therapeutics to Promote CNS MyelinationUH2TR000918 · NCATS · UNIVERSITY OF CHICAGO · PI KRAIG, RICHARD P · 2013 to 2014
$568k
NCATS NIH HHS 1 UH 2 TR000918NCATS NIH HHS UH2 TR000918NCATS NIH HHS UL1 TR000430NCATS NIH HHS UL1TR000430NICHD NIH HHS 5 PO1 HD 09402NICHD NIH HHS P01 HD009402NIGMS NIH HHS 5T32GM007839-31NIGMS NIH HHS T32 GM007839NINDS NIH HHS NS-19108NINDS NIH HHS R01 NS019108
6 · The paper itself

Abstract

Dendritic cells (DCs) release exosomes with different characteristics based on stimulus. Here, we showed that DC cultures stimulated with low-level IFNγ released exosomes (IFNγ-DC-Exos) that contained microRNA species that can increase baseline myelination, reduce oxidative stress, and improve remyelination following acute lysolecithin-induced demyelination. Furthermore, nasally administered IFNγ-DC-Exos increased CNS myelination in vivo. IFNγ-DC-Exos were preferentially taken up by oligodendrocytes, suggesting that they directly impact oligodendrocytes to increase myelination. Thus, our results show great potential for use of these IFNγ-DC-Exos as a therapeutic to promote remyelination in multiple sclerosis and dysmyelinating syndromes.

Indexed as

AnimalsAnimals, NewbornCell DifferentiationCells, CulturedDemyelinating DiseasesDendritic CellsExosomesFemaleGlutathioneHippocampusInterferon-alphaIn Vitro TechniquesLysophosphatidylcholinesMaleMicrogliaMicroRNAsGlutathioneInterferon-alphaLysophosphatidylcholinesMicroRNAsDemyelinationDendritic cellExosomesMicroRNAMultiple sclerosisMyelin

Identifiers

PMID24275061
PMCPMC3920591
OpenAlexW1987523416

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.