ArticleAnalytical chemistry2014
On the direct electron transfer, sensing, and enzyme activity in the glucose oxidase/carbon nanotubes system.
Article in Analytical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 239 citations in OpenAlex.
- Layer-by-Layer Assembly of Glucose Oxidase on Carbon Nanotube Modified Electrodes.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Cobalt-Based Ferrite Modified Carbon Nanotubes Fibers for Flexible and Disposable Microelectrode Toward Electrochemical Glucose Sensing.Analytical science advances · 2024Article
- Dipole moment as the underlying mechanism for enhancing the immobilization of glucose oxidase by ferrocene-chitosan for superior specificity non-invasive glucose sensing.Nanoscale advances · 2023Article
- Covalent conjugation of proteins onto fluorescent single-walled carbon nanotubes for biological and medical applications.Materials advances · 2023Review
- Electrochemical Response of Glucose Oxidase Adsorbed on Laser-Induced Graphene.Nanomaterials (Basel, Switzerland) · 2021Article
- A Fluidics-Based Biosensor to Detect and Characterize Inhibition Patterns of Organophosphate to Acetylcholinesterase in Food Materials.Micromachines · 2021Article
- 2D metal azolate framework as nanozyme for amperometric detection of glucose at physiological pH and alkaline medium.Mikrochimica acta · 2021Article
- Disposable and Low-Cost Colorimetric Sensors for Environmental Analysis.International journal of environmental research and public health · 2020Review
- Poly(9Biosensors · 2020Article
- Biofuel powered glucose detection in bodily fluids with an n-type conjugated polymer.Nature materials · 2020Article
- Predicting Protein-Polymer Block Copolymer Self-Assembly from Protein Properties.Biomacromolecules · 2019Article
- Nitrogen-containing three-dimensional biomass porous carbon materials as an efficient enzymatic biosensing platform for glucose sensing.RSC advances · 2019Article
- Silver Nanoparticle Formation-Based Colorimetric Determination of Reducing Sugars in Food Extracts via Tollens' Reagent.ACS omega · 2019Article
- Visual distance readout to display the level of energy generation in paper-based biofuel cells: application to enzymatic sensing of glucose.Mikrochimica acta · 2019Article
- A review on graphene-based nanocomposites for electrochemical and fluorescent biosensors.RSC advances · 2019Review
- Enzymatic self-wiring in nanopores and its application in direct electron transfer biofuel cells.Nanoscale advances · 2019Article
- Electrodeposition⁻Assisted Assembled Multilayer Films of Gold Nanoparticles and Glucose Oxidase onto Polypyrrole-Reduced Graphene Oxide Matrix and Their Electrocatalytic Activity toward Glucose.Nanomaterials (Basel, Switzerland) · 2018Article
- Sensitive Fluorescent Sensor for Recognition of HIV-1 dsDNA by Using Glucose Oxidase and Triplex DNA.Journal of analytical methods in chemistry · 2018Article
- Direct enzymatic bioelectrocatalysis: differentiating between myth and reality.Journal of the Royal Society, Interface · 2017Review
- Smart Nanocomposites of Cu-Hemin Metal-Organic Frameworks for Electrochemical Glucose Biosensing.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The signal transduction and enzyme activity were investigated in biosensors based on the glucose oxidase (GOx) and carbon nanotubes (CNT) embedded in a bioadhesive film of chitosan (CHIT). The voltammetric studies showed that, regardless of CHIT matrix, the GOx adsorbed on CNT yielding a pair of surface-confined current peaks at -0.48 V. The anodic peak did not increase in the presence of glucose in an O2-free solution indicating the lack of direct electron transfer (DET) between the enzymatically active GOx and CNT. The voltammetric peaks were due to the redox of enzyme cofactor flavin adenine dinucleotide (FAD), which was not the part of active enzyme. The presented data suggest that DET may not be happening for any type of GOx/CNT-based sensor. The biosensor was sensitive to glucose in air-equilibrated solutions indicating the O2-mediated enzymatic oxidation of glucose. The signal transduction relied on the net drop in a biosensor current that was caused by a decrease in a 4-e(-) O2 reduction current and an increase in a 2-e(-) H2O2 reduction current. The enzyme assays showed that CNT nearly doubled the retention of GOx in a biosensor while decreasing the average enzymatic activity of retained enzyme by a factor of 4-5. Such inhibition should be considered when using a protein-assisted solubilization of CNT in water for biomedical applications. The proposed analytical protocols can be also applied to study the effects of nanoparticles on proteins in assessing the health risks associated with the use of nanomaterials.
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