Evidence map›Paper›PMID 24274654›Full record

ArticleEmerging infectious diseases2013

Zoonotic Chlamydiaceae species associated with trachoma, Nepal.

Deborah Dean, James Rothschild, Anke Ruettger, Ram Prasad Kandel, Konrad Sachse

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Pangenome-Wide Association Study in theInternational journal of molecular sciences · 2024
    Article
  8. Chlamydiosis in Animals.Animals : an open access journal from MDPI · 2024
    Review
  9. Article
  10. Seroprevalence and Risk Factors ofVector borne and zoonotic diseases (Larchmont, N.Y.) · 2024
    Article
  11. Review
  12. Frontiers in cell and developmental biology · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. The Impact of Lateral Gene Transfer inFrontiers in cellular and infection microbiology · 2022
    Review
  19. Characteristics ofPathogens (Basel, Switzerland) · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Deborah Dean
James Rothschild
Anke Ruettger
Ram Prasad Kandel
Konrad Sachse
University of California, Berkeley · USFriedrich-Loeffler-Institut · DEUniversity of California, San Francisco · US

Funding

Multiplex diagnostic for biothreat C. psittaci & non-threat respiratory pathogensR01AI098843 · NIAID · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI DEAN, DEBORAH ANNE, READ, TIMOTHY D. · 2012 to 2016
$5.5M
NIAID NIH HHS R01 AI098843
6 · The paper itself

Abstract

Trachoma is the leading cause of preventable blindness. Commercial assays do not discriminate among all Chlamydiaceae species that might be involved in trachoma. We investigated whether a commercial Micro-ArrayTube could discriminate Chlamydiaceae species in DNA extracted directly from conjunctival samples from 101 trachoma patients in Nepal. To evaluate organism viability, we extracted RNA, reverse transcribed it, and subjected it to quantitative real-time PCR. We found that 71 (70.3%) villagers were infected. ArrayTube sensitivity was 91.7% and specificity was 100% compared with that of real-time PCR. Concordance between genotypes detected by microarray and ompA genotyping was 100%. Species distribution included 54 (76%) single infections with Chlamydia trachomatis, C. psittaci, C. suis, or C. pecorum, and 17 (24%) mixed infections that includied C. pneumoniae. Ocular infections were caused by 5 Chlamydiaceae species. Additional studies of trachoma pathogenesis involving Chlamydiaceae species other than C. trachomatis and their zoonotic origins are needed.

Indexed as

AdolescentBacterial Outer Membrane ProteinsChildChild, PreschoolChlamydiaceaeChlamydia trachomatisFemaleGenotypeHumansInfantMaleNepalTrachomaBacterial Outer Membrane ProteinsOMPA outer membrane proteinsbacteriaChlamydiaceaemicroarrayNepalspecies and strain typingtrachomazoonoseszoonotic transmission

Identifiers

PMID24274654
PMCPMC3840858
OpenAlexW2053292987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.