Evidence map›Paper›PMID 24274545›Full record

ArticleCarbohydrate polymers2014

Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-κB and endothelial inflammatory response.

Yu Li, Hongtao Liu, Qing-Song Xu, Yu-Guang Du, Jian Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Carbohydrate polymers, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Frontiers in immunology · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. O-GlcNAcylation dictates pyroptosis.Frontiers in immunology · 2024
    Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Yu LiDalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences, Beijing 100049, China; Department of Medicine, University of Oklahoma Health Sciences Center, 941 Stanton L. Young Boulevard, Oklahoma City, OK 73104, USA.
Hongtao Liu
Qing-Song Xu
Yu-Guang Du
Jian Xu
University of Oklahoma Health Sciences Center · USChinese Academy of Sciences · CNDalian Institute of Chemical Physics · CNUniversity of Chinese Academy of Sciences · CN

Funding

THE ROLE OF COMPLEX 1 IN MITOCHONDRIAL DYSFUNCTION & FREE RADICAL PROD IN TYPE 1P20RR024215 · NCRR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI XIE, ZHONGLIN · 2007 to 2011
$11.7M
Project 5 VEGF Signaling in PhotoreceptorsP20GM104934 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HAYS, FRANKLIN ALAN · 2012 to 2016
$10.8M
American Heart Association-American Stroke Association 10SDG2600164American Heart Association-American Stroke Association 14BGIA20030027NCRR NIH HHS P20 RR024215NCRR NIH HHS P20 RR 024215-05NIGMS NIH HHS 9P20GM104934-06NIGMS NIH HHS P20 GM104934
6 · The paper itself

Abstract

It is known that chitosan oligosaccharides (COS) suppress LPS-induced vascular endothelial inflammatory response by mechanism involving NF-κB blockade. It remains unknown how COS inhibit NF-κB. We provided evidence both in cultured endothelial cells and mouse model supporting a new mechanism. Regardless of the endothelial cell types, the LPS-induced NF-κB-dependent inflammatory gene expression was suppressed by COS, which was associated with reduced NF-κB nucleus translocation. LPS enhanced O-GlcNAc modification of NF-κB/p65 and activated NF-κB pathway, which could be prevented either by siRNA knockdown of O-GlcNAc transferase (OGT) or pretreatment with COS. Inhibition of either mitogen-activated protein kinase or superoxide generation abolishes LPS-induced NF-κB O-GlcNAcylation. Consistently, aortic tissues from LPS-treated mice presented enhanced NF-κB/p65 O-GlcNAcylation in association with upregulated gene expression of inflammatory cytokines in vascular tissues; however, pre-administration of COS prevented these responses. In conclusion, COS decreased OGT-dependent O-GlcNAcylation of NF-κB and thereby attenuated LPS-induced vascular endothelial inflammatory response.

Indexed as

AcetylglucosamineAcylationAnimalsCattleCells, CulturedChitosanEndothelial CellsGene Expression RegulationHumansInflammationLipopolysaccharidesMiceN-AcetylglucosaminyltransferasesOligosaccharidesProtein TransportSignal TransductionAcetylglucosamineChitosanLipopolysaccharidesN-AcetylglucosaminyltransferasesO-GlcNAc transferaseOligosaccharidesTranscription Factor RelAChitosan oligosaccharidesEndothelial cellsInflammatory responseLipopolysaccharides (LPS)Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)O-GlcNAcylation

Identifiers

PMID24274545
PMCPMC3843148
OpenAlexW2031215262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.